11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidin-4(3H)-thione

Base Information

• Chemical Name: 11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidin-4(3H)-thione
• CAS No.: 141693-60-9
• Molecular Formula: C₁₉H₁₄ClN₃S₂
• Molecular Weight: 383.925
• Mol file: 141693-60-9.mol

Synonyms:

Chemical Property of 11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidin-4(3H)-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidin-4(3H)-thione

There total 3 articles about 11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidin-4(3H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

4-Chloro-11-(p-chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidine (141693-59-6) → 11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidin-4(3H)-thione (141693-60-9)

Guidance literature:

With thiourea; In isopropyl alcohol; for 3h; Heating;

Reference yield:

3-Amino-4-(p-chlorophenyl)-5,6,7,8-tetrahydro-thieno<2,3-b>quinoline-2-carboxamide (117601-30-6) → 11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidin-4(3H)-thione (141693-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / acetic anhydride / 1 h / 120 °C

2: 83 percent / POCl₃ / 3 h / Heating

3: 31 percent / thiourea / propan-2-ol / 3 h / Heating

With thiourea; trichlorophosphate; In acetic anhydride; isopropyl alcohol;

Reference yield:

11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidine-4(3H)-one (141693-57-4) → 11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidin-4(3H)-thione (141693-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / POCl₃ / 3 h / Heating

2: 31 percent / thiourea / propan-2-ol / 3 h / Heating

With thiourea; trichlorophosphate; In isopropyl alcohol;

upstream raw materials:

4-Chloro-11-(p-chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidine

3-Amino-4-(p-chlorophenyl)-5,6,7,8-tetrahydro-thieno<2,3-b>quinoline-2-carboxamide

11-(p-Chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidine-4(3H)-one

Downstream raw materials:

4-Methylthio-11-(p-chlorophenyl)-7,8,9,10-tetrahydroquinolino<3',2':4,5>thieno<3,2-d>pyrimidine