Boc-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-OH

Base Information

Chemical Name:Boc-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-OH
CAS No.:78841-36-8
Molecular Formula:C₅₉H₇₄ClN₉O₁₅
Molecular Weight:1184.74
Hs Code.:

Boc-Phe-D-Trp-Lys<Z(pCl)>-Thr-Phe-Thr-Ser-OH

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Boc-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-OH

Chemical Property:

Purity/Quality:

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Technology Process of Boc-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-OH

There total 9 articles about Boc-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78841-35-7
Boc-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-OMe

: 78841-36-8
Boc-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-OH

Guidance literature:: With sodium hydroxide; In methanol; N,N-dimethyl-formamide; for 12h; Ambient temperature;

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 78841-36-8
Boc-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-OH

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Chlorkohlensaeureisobutylester, NEt₃; 2.) NEt₃ / 1.) 6 min, -15 deg C, THF, 2.) 1 h, -15 deg C, 12 h, room temp., THF

2: 97 percent / aq. NaOH / acetone / 2 h

3: 1.) Chlorkohlensaeureisobutylester, NEt₃; 2) NEt₃ / 1.) 6 min, -15 deg C, THF; 2.) 2 h, -15 deg C, 12 h, room temp.

4: aq. NaOH / dimethylformamide; dioxane / 12 h / Ambient temperature

5: 91 percent / HOBt, DCCI, N-methylmorpholine / dimethylformamide / 1.) 2 h, 0 deg C; 2.) 12 h, room temp.

6: NaOH, (1 mol/l) / methanol; dimethylformamide / 12 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetone;

Reference yield:

: 14907-27-8,5619-09-0,7524-52-9,26988-71-6,41222-70-2,67557-19-1,109492-62-8
(R)-(+)-tryptophan methyl ester hydrochloride

: 78841-36-8
Boc-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-OH

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Chlorkohlensaeureisobutylester, NEt₃; 2.) NEt₃ / 1.) 6 min, -15 deg C, THF, 2.) 1 h, -15 deg C, 12 h, room temp., THF

2: 97 percent / aq. NaOH / acetone / 2 h

3: 1.) Chlorkohlensaeureisobutylester, NEt₃; 2) NEt₃ / 1.) 6 min, -15 deg C, THF; 2.) 2 h, -15 deg C, 12 h, room temp.

4: aq. NaOH / dimethylformamide; dioxane / 12 h / Ambient temperature

5: 91 percent / HOBt, DCCI, N-methylmorpholine / dimethylformamide / 1.) 2 h, 0 deg C; 2.) 12 h, room temp.

6: NaOH, (1 mol/l) / methanol; dimethylformamide / 12 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetone;