methyl 3-chloro-2,4,6-trihydroxybenzoate

Base Information

• Chemical Name: methyl 3-chloro-2,4,6-trihydroxybenzoate
• CAS No.: 10387-87-8
• Molecular Formula: C₈H₇ClO₅
• Molecular Weight: 218.594
• Mol file: 10387-87-8.mol

Synonyms:

Chemical Property of methyl 3-chloro-2,4,6-trihydroxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-chloro-2,4,6-trihydroxybenzoate

There total 1 articles about methyl 3-chloro-2,4,6-trihydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,4,6-trihydroxybenzoate (3147-39-5) → methyl 3-chloro-2,4,6-trihydroxybenzoate (10387-87-8)

Guidance literature:

With sulfuryl dichloride;

Reference yield:

methyl 3-chloro-2,4,6-trihydroxybenzoate (10387-87-8) → 6-(3-Chloro-2,4,6-trihydroxy-5-(2-methylbutanoyl)benzyl)-3-ethyl-5,7-dihydroxy-8-methylchroman-4-one

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-aniline / 150 °C

2: boron trifluoride diethyl etherate / 70 °C

3: zinc(II) chloride / 1,4-dioxane / 12 h / Reflux

With boron trifluoride diethyl etherate; N,N-dimethyl-aniline; zinc(II) chloride; In 1,4-dioxane; 2: |Friedel-Crafts Acylation;

DOI:10.1021/acsinfecdis.8b00325

Reference yield:

methyl 3-chloro-2,4,6-trihydroxybenzoate (10387-87-8) → 3-Chlor-2,4,6-trihydroxy-benzamid (3187-17-5)

Guidance literature:

With ammonium hydroxide;

upstream raw materials:

methyl 2,4,6-trihydroxybenzoate

Downstream raw materials:

3-Chlor-2,4,6-trihydroxy-benzamid