(S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid

Base Information

• Chemical Name: (S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid
• CAS No.: 183444-90-8
• Molecular Formula: C₄₈H₄₈N₄O₈
• Molecular Weight: 808.931

Synonyms:

Chemical Property of (S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid

There total 4 articles about (S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-phenylalanine tert-butyl ester (16874-17-2) → (S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid (183444-90-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) N-hydroxypyrrolidine-2,5-dione, DCC / 1.) THF, 0 deg C, 2 h, 2.) THF, RT, overnight

2: 87 percent / 2 M aq. HBr / acetic acid

3: 1.) N-hydroxypyrrolidine-2,5-dione, DCC, 2.) NMM / 1.) THF, CH₂Cl₂, a) 0 deg C, 2 h, b) RT, overnight, 2.) THF, CH₂Cl₂, H₂O, a) 0 deg C, 2 h, b) from 0 deg C to RT, 12 h

With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen bromide; dicyclohexyl-carbodiimide; In acetic acid;

DOI:10.1055/s-1996-4368

Reference yield:

N-(9-fluorenylmethoxycarbonyl)-D-alanine (35661-38-2,35661-39-3,79990-15-1,136132-75-7) → (S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid (183444-90-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) N-hydroxypyrrolidine-2,5-dione, DCC / 1.) THF, 0 deg C, 2 h, 2.) THF, RT, overnight

2: 87 percent / 2 M aq. HBr / acetic acid

3: 1.) N-hydroxypyrrolidine-2,5-dione, DCC, 2.) NMM / 1.) THF, CH₂Cl₂, a) 0 deg C, 2 h, b) RT, overnight, 2.) THF, CH₂Cl₂, H₂O, a) 0 deg C, 2 h, b) from 0 deg C to RT, 12 h

With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen bromide; dicyclohexyl-carbodiimide; In acetic acid;

DOI:10.1055/s-1996-4368

Reference yield:

D-(N-9-fluorenylmethoxycarbonylalanyl)-L-phenylalanine tert-butyl ester (183444-88-4) → (S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid (183444-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / 2 M aq. HBr / acetic acid

2: 1.) N-hydroxypyrrolidine-2,5-dione, DCC, 2.) NMM / 1.) THF, CH₂Cl₂, a) 0 deg C, 2 h, b) RT, overnight, 2.) THF, CH₂Cl₂, H₂O, a) 0 deg C, 2 h, b) from 0 deg C to RT, 12 h

With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen bromide; dicyclohexyl-carbodiimide; In acetic acid;

DOI:10.1055/s-1996-4368

upstream raw materials:

N-(fluorenyl-9-methoxycarbonyl)-L-lysine

D-(N-9-fluorenylmethoxycarbonylalanyl)-L-phenylalanine

L-phenylalanine tert-butyl ester

N-(9-fluorenylmethoxycarbonyl)-D-alanine

Downstream raw materials:

N-(2-chloroethyl)-N'-methyl-N'-{2-[D-(N-9-fluorenylmethoxycarbonylalanyl)-L-phenylalanyl-L-(N^ω-9-fluorenylmethoxycarbonyllysyl)amino]ethyl}-N-nitrosourea

N-(2-chloroethyl)-N'-methyl-N'-[2-(D-alanyl-L-phenylalanyl-L-lysyl-amino)ethyl]-N-nitrosourea

((S)-5-[2-(tert-Butoxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-pentyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 183444-90-8 (S)-6-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-phenyl-propionylamino}-hexanoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send