Technology Process of 2-(tert-butylsulphonyl)ethyl N6-(diphenylacetyl)-2'-deoxy-3'-adenosyl 1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl phosphate
There total 10 articles about 2-(tert-butylsulphonyl)ethyl N6-(diphenylacetyl)-2'-deoxy-3'-adenosyl 1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl phosphate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
chloroform;
for 0.00833333h;
Yield given;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) pyridine; 2.) pyridine / 1.) 30 min; 2.) dioxane, 1 h, r.t.
2: cc. aq. NH3 / H2O; pyridine; dioxane / 0.5 h / Ambient temperature
3: pyridine / 0.5 h / Ambient temperature
4: HOBt / acetonitrile; tetrahydrofuran / 0.17 h / Ambient temperature
5: I2, 2,6-lutidine / tetrahydrofuran; H2O / -10 °C
6: TFA / CHCl3 / 0.01 h
With
pyridine; 2,6-dimethylpyridine; ammonium hydroxide; iodine; benzotriazol-1-ol; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; pyridine; chloroform; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / EtN(i-Pr)2 / CH2Cl2 / 0.08 h / Ambient temperature
2: HOBt / acetonitrile; tetrahydrofuran / 0.17 h / Ambient temperature
3: I2, 2,6-lutidine / tetrahydrofuran; H2O / -10 °C
4: TFA / CHCl3 / 0.01 h
With
2,6-dimethylpyridine; iodine; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; chloroform; water; acetonitrile;
