(2S,2aS,4aS,6S,7aR,7bR)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopentindene-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,2aS,4aS,6S,7aR,7bR)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopentindene-2-carboxylic acid methyl ester
CAS No.:137572-09-9
Molecular Formula:C₂₃H₃₁NO₅
Molecular Weight:401.503
Hs Code.:

(2S,2aS,4aS,6S,7aR,7bR)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopent<cd>indene-2-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,2aS,4aS,6S,7aR,7bR)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopentindene-2-carboxylic acid methyl ester

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Technology Process of (2S,2aS,4aS,6S,7aR,7bR)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopentindene-2-carboxylic acid methyl ester

There total 4 articles about (2S,2aS,4aS,6S,7aR,7bR)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopentindene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124126-07-4
(2E,6E)-methyl 7-nitro-2,6-octadienoate

: 135500-31-1,127598-16-7
(1R,2S)-2-phenylcyclohexyl vinyl ether

: 137624-84-1
(2S,2aR,4aR,6R,7aR,7bS)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopentindene-2-carboxylic acid methyl ester

: 137572-09-9,137624-83-0,137624-84-1
(2R,2aR,4aR,6R,7bS)-7b-Methyl-6-((1R,2S)-2-phenyl-cyclohexyloxy)-octahydro-1,7-dioxa-7a-aza-cyclopenta[cd]indene-2-carboxylic acid methyl ester

Guidance literature:: methylaluminium bis(2,6-diphenylphenoxide); In dichloromethane; at -78 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00024a005

Reference yield:

: 98919-68-7
(1R,2S)-trans-2-phenylcyclohexanol

: 137572-09-9
(2S,2aS,4aS,6S,7aR,7bR)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopentindene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / mercuric acetate / 12 h / Heating

2: 2,6-diphenylphenol, Me₃Al / CH₂Cl₂ / 1) -78 deg C, 3 h, 2) r.t., 10 h

With (1,1';3',1''-terphenyl)-2'-ol; mercury(II) diacetate; trimethylaluminum; In dichloromethane;
DOI:10.1021/jo00059a044

Reference yield:

: 124126-07-4
(2E,6E)-methyl 7-nitro-2,6-octadienoate

: 135500-31-1,127598-16-7
(1R,2S)-2-phenylcyclohexyl vinyl ether

: 137572-09-9
(2S,2aS,4aS,6S,7aR,7bR)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopentindene-2-carboxylic acid methyl ester

: 137624-83-0
(2S,2aS,4aS,6R,7aR,7bR)-6-<(1R,2S)-2-(phenylcyclohexyl)oxy>octahydro-7b-methyl-1,7-dioxa-7a-azacyclopentindene-2-carboxylic acid methyl ester

Guidance literature:: With titanium(IV) dichlorodiisopropylate; In dichloromethane; at -78 ℃; for 3h; Product distribution; further Lewis acids: methyl aluminium bis(2,6-di tert-butyl-4-methylphenoxide (MAD), methyl aluminium bis(2,6-diphenylphenoxide); further chiral enol ethers; stereocontrol;
DOI:10.1021/jo00059a044