(S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Base Information

Chemical Name:(S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester
CAS No.:204376-51-2
Molecular Formula:C₄₃H₅₅Cl₄N₃O₉
Molecular Weight:899.736
Hs Code.:

(S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Synonyms:

Suppliers and Price of (S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

There total 7 articles about (S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6914-79-0
1-cyano-cyclopropanecarboxylic acid

: 204376-51-2
(S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / H₂, HOAc / Pt₂O

2: 93 percent / NaOH / dioxane

3: EDCI, HOBt

With sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Adam’s catalyst; In 1,4-dioxane;
DOI:10.1016/S0960-894X(98)00748-3

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 204376-51-2
(S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / DCC, DMAP / CH₂Cl₂

2: TFA

3: EDCI, HOBt

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(98)00748-3

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 204376-51-2
(S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / NaOH / dioxane

2: EDCI, HOBt

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane;
DOI:10.1016/S0960-894X(98)00748-3