Technology Process of (5Z,7E,11Z,14Z)-9-(tert-Butyl-diphenyl-silanyloxy)-icosa-5,7,11,14-tetraenoic acid
There total 11 articles about (5Z,7E,11Z,14Z)-9-(tert-Butyl-diphenyl-silanyloxy)-icosa-5,7,11,14-tetraenoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: paralleled the route described for diazo-ketone 6
2: 2
3: NaBH4/CeCl3 / propan-2-ol; H2O / 0 °C
4: pyridine / -10 °C
5: imidazole / dimethylformamide / 0 °C
6: H2 / Lindlar / hexane; pyridine
7: 80percent AcOH / tetrahydrofuran; H2O
8: 95 percent / CBr4(Ph2PCH2)2 / CH2Cl2 / 0 °C
9: 50 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -40 deg C to RT, overnight
10: DCC/py/TFA / benzene; dimethylsulfoxide / 16 h / Ambient temperature
11: NaClO2 / 2-methyl-propan-2-ol; H2O
With
pyridine; 1H-imidazole; sodium chlorite; sodium tetrahydroborate; cerium(III) chloride; CBr4(Ph2PCH2)2; hydrogen; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid;
dirhodium tetraacetate; Lindlar's catalyst;
In
tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(01)91141-4
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 2
2: NaBH4/CeCl3 / propan-2-ol; H2O / 0 °C
3: pyridine / -10 °C
4: imidazole / dimethylformamide / 0 °C
5: H2 / Lindlar / hexane; pyridine
6: 80percent AcOH / tetrahydrofuran; H2O
7: 95 percent / CBr4(Ph2PCH2)2 / CH2Cl2 / 0 °C
8: 50 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -40 deg C to RT, overnight
9: DCC/py/TFA / benzene; dimethylsulfoxide / 16 h / Ambient temperature
10: NaClO2 / 2-methyl-propan-2-ol; H2O
With
pyridine; 1H-imidazole; sodium chlorite; sodium tetrahydroborate; cerium(III) chloride; CBr4(Ph2PCH2)2; hydrogen; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid;
dirhodium tetraacetate; Lindlar's catalyst;
In
tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(01)91141-4
- Guidance literature:
-
Multi-step reaction with 9 steps
1: NaBH4/CeCl3 / propan-2-ol; H2O / 0 °C
2: pyridine / -10 °C
3: imidazole / dimethylformamide / 0 °C
4: H2 / Lindlar / hexane; pyridine
5: 80percent AcOH / tetrahydrofuran; H2O
6: 95 percent / CBr4(Ph2PCH2)2 / CH2Cl2 / 0 °C
7: 50 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -40 deg C to RT, overnight
8: DCC/py/TFA / benzene; dimethylsulfoxide / 16 h / Ambient temperature
9: NaClO2 / 2-methyl-propan-2-ol; H2O
With
pyridine; 1H-imidazole; sodium chlorite; sodium tetrahydroborate; cerium(III) chloride; CBr4(Ph2PCH2)2; hydrogen; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid;
Lindlar's catalyst;
In
tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(01)91141-4
