2-methyl-3-(5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazol-4-yl)thieno[3,2-b]pyridine

Base Information

• Chemical Name: 2-methyl-3-(5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazol-4-yl)thieno[3,2-b]pyridine
• CAS No.: 1343500-22-0
• Molecular Formula: C₂₆H₁₈N₂S₃
• Molecular Weight: 454.64
• Mol file: 1343500-22-0.mol

Synonyms:

Chemical Property of 2-methyl-3-(5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazol-4-yl)thieno[3,2-b]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3-(5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazol-4-yl)thieno[3,2-b]pyridine

There total 6 articles about 2-methyl-3-(5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazol-4-yl)thieno[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thieno[3,2-b]pyridine (1343500-27-5) + 4-bromo-5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole (1343500-28-6) → 2-methyl-3-(5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazol-4-yl)thieno[3,2-b]pyridine (1343500-22-0)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In 1,4-dioxane; water; at 100 ℃; for 72h; Inert atmosphere;

DOI:10.1002/chem.201101495

Reference yield:

3-iodo-2-methylthieno[3,2-b]pyridine (1343500-26-4) → 2-methyl-3-(5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazol-4-yl)thieno[3,2-b]pyridine (1343500-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; water / 72 h / 100 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; triphenylphosphine; In 1,4-dioxane; diethyl ether; hexane; water;

DOI:10.1002/chem.201101495

Reference yield:

2-bromo-3-(methylthio)pyridine (884863-17-6) → 2-methyl-3-(5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazol-4-yl)thieno[3,2-b]pyridine (1343500-22-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; triethylamine / tetrahydrofuran / 15 h / 40 °C / Inert atmosphere

2.1: iodine / dichloromethane / 2 h / 20 °C

3.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C

4.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; water / 72 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutyl ammonium fluoride; iodine; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; water;

DOI:10.1002/chem.201101495

upstream raw materials:

2-bromo-3-(methylthio)pyridine

2,3-dibromopyridine

2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thieno[3,2-b]pyridine

4-bromo-5-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole