C₁₄H₁₂Cl₂N₂O₂

Base Information

• Chemical Name: C₁₄H₁₂Cl₂N₂O₂
• CAS No.: 1306233-16-8
• Molecular Formula: C₁₄H₁₂Cl₂N₂O₂
• Molecular Weight: 311.167
• Mol file: 1306233-16-8.mol

Synonyms:

Chemical Property of C₁₄H₁₂Cl₂N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₂Cl₂N₂O₂

There total 3 articles about C₁₄H₁₂Cl₂N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H10Cl2N2O4 (1350292-82-8) → C14H12Cl2N2O2 (1306233-16-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2011.09.046

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → C14H12Cl2N2O2 (1306233-16-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 24 h / 20 °C

2: trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 12 h / Inert atmosphere; Reflux

3: palladium on activated charcoal; hydrogen / tetrahydrofuran / 4 h / 20 °C

With thionyl chloride; trans-bis(triphenylphosphine)palladium dichloride; palladium on activated charcoal; hydrogen; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2011.09.046

Reference yield:

4-fluoro-3-nitro-benzoic acid methyl ester (329-59-9) → C14H12Cl2N2O2 (1306233-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 12 h / Inert atmosphere; Reflux

2: palladium on activated charcoal; hydrogen / tetrahydrofuran / 4 h / 20 °C

With trans-bis(triphenylphosphine)palladium dichloride; palladium on activated charcoal; hydrogen; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2011.09.046

upstream raw materials:

C₁₄H₁₀Cl₂N₂O₄

3-nitro-4-fluorobenzoic acid

4-fluoro-3-nitro-benzoic acid methyl ester

Downstream raw materials:

C₁₆H₁₂Cl₂N₂O₃

C₁₇H₁₄Cl₂N₂O₃

C₂₈H₂₉Cl₂N₅O₃

C₁₆H₁₃Cl₃N₂O₃