1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide

Base Information

Chemical Name:1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide
CAS No.:1351800-62-8
Molecular Formula:BrH*C₃₁H₄₃N₃O₅
Molecular Weight:618.611
Hs Code.:

1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide

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Chemical Property of 1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide

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Technology Process of 1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide

There total 10 articles about 1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 474554-48-8
2-bromo-1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]ethanone

: 1351800-54-8
5,6-diethoxy-2,3-dihydro-3,3-dimethyl-1H-isoindol-1-imine

: 1351800-62-8
1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1002/hlca.201100128

Reference yield:

: 1351800-46-8
ethyl 2-bromo-4,5-diethoxybenzoate

: 1351800-62-8
1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 0.5 h / -5 - 0 °C / Inert atmosphere

2: methanesulfonic acid / dichloromethane / 1 h / 20 °C

3: N,N-dimethyl-formamide / 5 h / Inert atmosphere; Reflux

4: sodium azide / trifluoroacetic acid / 12 h / 20 °C

5: Raney-Ni / isopropyl alcohol / 12 h / Inert atmosphere; Reflux

6: tetrahydrofuran / 12 h / 20 °C

With sodium azide; methanesulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; trifluoroacetic acid;
DOI:10.1002/hlca.201100128

Reference yield:

: 1351800-47-9
2-(2-bromo-4,5-diethoxyphenyl)propan-2-ol

: 1351800-62-8
1-[3-(tert-butyl)-4-methoxy-5-(morpholin-4-yl)phenyl]-2-(5,6-diethoxy-1,3-dihydro-3-imino-1,1-dimethyl-1H-isoindol-2-yl)ethanone hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: methanesulfonic acid / dichloromethane / 1 h / 20 °C

2: N,N-dimethyl-formamide / 5 h / Inert atmosphere; Reflux

3: sodium azide / trifluoroacetic acid / 12 h / 20 °C

4: Raney-Ni / isopropyl alcohol / 12 h / Inert atmosphere; Reflux

5: tetrahydrofuran / 12 h / 20 °C

With sodium azide; methanesulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; trifluoroacetic acid;
DOI:10.1002/hlca.201100128