(2S,3R)-2-Methyl-3-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid 1-ethyl-propyl ester

Base Information

• Chemical Name: (2S,3R)-2-Methyl-3-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid 1-ethyl-propyl ester
• CAS No.: 1000615-96-2
• Molecular Formula: C₂₁H₂₉F₃O₅
• Molecular Weight: 418.453
• Mol file: 1000615-96-2.mol

Synonyms:

Chemical Property of (2S,3R)-2-Methyl-3-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid 1-ethyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-2-Methyl-3-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid 1-ethyl-propyl ester

There total 7 articles about (2S,3R)-2-Methyl-3-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid 1-ethyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-2-penten-1-ol (1576-95-0) → (2S,3R)-2-Methyl-3-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid 1-ethyl-propyl ester (1000615-96-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) 4A molecular sieve, Ti(OiPr)4, L-(+)-diisopropyl tartrate, t-butylhydroperoxide; 2) triethylamine / 1) CH₂Cl₂, -15-(-5) deg C, 10 h; 2) CH₂Cl₂, 0 deg C, 1 h

2: 88 percent / NaOH / tetrahydrofuran; H₂O / 0.5 h / Ambient temperature

3: 875 mg / RuCl_3.3H₂O, NaIO₄ / CCl₄; acetonitrile; H₂O / 3 h / Ambient temperature

4: 4-dimethylaminopyridine, 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 0 deg C, 1 h; r.t., 3 h

5: 69 percent / diethyl ether / 2 h / -20 °C

6: Et₃N, 4-dimethylaminopyridine / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; ruthenium trichloride; sodium hydroxide; sodium periodate; L-(+)-diisopropyl tartrate; 4 A molecular sieve; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; acetonitrile;

DOI:10.1016/0040-4020(89)80090-0

Reference yield:

2-pentanol (584-02-1) → (2S,3R)-2-Methyl-3-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid 1-ethyl-propyl ester (1000615-96-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-dimethylaminopyridine, 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 0 deg C, 1 h; r.t., 3 h

2: 69 percent / diethyl ether / 2 h / -20 °C

3: Et₃N, 4-dimethylaminopyridine / CH₂Cl₂

With dmap; triethylamine; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;

DOI:10.1016/0040-4020(89)80090-0

Reference yield:

[(2S,3R)-3-ethyloxiran-2-yl]methanol (106034-58-6) → (2S,3R)-2-Methyl-3-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid 1-ethyl-propyl ester (1000615-96-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 875 mg / RuCl_3.3H₂O, NaIO₄ / CCl₄; acetonitrile; H₂O / 3 h / Ambient temperature

2: 4-dimethylaminopyridine, 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 0 deg C, 1 h; r.t., 3 h

3: 69 percent / diethyl ether / 2 h / -20 °C

4: Et₃N, 4-dimethylaminopyridine / CH₂Cl₂

With dmap; ruthenium trichloride; sodium periodate; triethylamine; dicyclohexyl-carbodiimide; In tetrachloromethane; diethyl ether; dichloromethane; water; acetonitrile;

DOI:10.1016/0040-4020(89)80090-0

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(2S,3R) 1'-ethylpropyl 3-hydroxy-2-methylpentanoate

cis-2-penten-1-ol

2-pentanol