(3S,5S)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene

Base Information

Chemical Name:(3S,5S)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene
CAS No.:87095-80-5
Molecular Formula:C₁₉H₂₂O₂
Molecular Weight:282.382
Hs Code.:

Synonyms:

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Chemical Property of (3S,5S)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene

Chemical Property:

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Technology Process of (3S,5S)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene

There total 7 articles about (3S,5S)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₆O₃

: 1449-46-3
benzyltriphenylphosphonium bromide

: C₁₉H₂₂O₂

: 87095-80-5
(3R,5R)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In dichloromethane; at 40 ℃; for 6h; Overall yield = 65 %; Overall yield = 0.132 g;
DOI:10.1002/ejoc.201801211

Reference yield:

: 93712-74-4,87095-74-7
(5R)-trans-1,7-diphenyl-5-hydroxyhept-6-en-3-one

: 87095-80-5
(3R,5R)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene

Guidance literature:: With sodium tetrahydroborate; In methanol; for 3h; Ambient temperature;

Reference yield:

: 3396-71-2
3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

: C₁₉H₂₂O₂

: 87095-80-5
(3R,5R)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; triphenylphosphine; carbon tetrabromide / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: copper(ll) sulfate pentahydrate / methanol; water / 1.5 h / 60 °C

4.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol

5.1: sulfuric acid / water; tetrahydrofuran / 4 h / 60 °C

6.1: potassium carbonate; 18-crown-6 ether / dichloromethane / 6 h / 40 °C

With copper(ll) sulfate pentahydrate; 18-crown-6 ether; carbon tetrabromide; sulfuric acid; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201801211