3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro

Base Information

Chemical Name:3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro
CAS No.:84655-57-2
Molecular Formula:C₂₃H₂₉NO₂
Molecular Weight:351.489
Hs Code.:

3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro<isobenzofuran-1,4'-pyran>

Synonyms:

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Chemical Property of 3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro

Chemical Property:

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Technology Process of 3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro

There total 3 articles about 3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 84655-57-2
3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro

Guidance literature:: Multi-step reaction with 3 steps

1: 2.2 N butyllithium / 1) THF, hexane, -60 to -70 deg C, 2 h, 2) -60 deg C, 3 h, r.t., overnight

2: 38 percent / conc. HCl / acetic acid / 0.5 h / Heating

3: 2.1 M n-butyllithium / 1) THF, hexane, -10 deg C, 1 h, 2) -10 deg C, 1 h, r.t., overnight

With hydrogenchloride; n-butyllithium; In acetic acid;

Reference yield:

: 84655-51-6
4-hydroxy-4-<2-(1-methoxy-1-phenylmethyl)phen-1-yl>-2,3,5,6-tetrahydropyran

: 84655-57-2
3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / conc. HCl / acetic acid / 0.5 h / Heating

2: 2.1 M n-butyllithium / 1) THF, hexane, -10 deg C, 1 h, 2) -10 deg C, 1 h, r.t., overnight

With hydrogenchloride; n-butyllithium; In acetic acid;

Reference yield:

: 60233-91-2
1,2',3,3',5',6'-hexahydro-3-phenylspiro

: 109-54-6
3-(Dimethylamino)propyl chloride

: 84655-57-2
3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1) THF, hexane, -10 deg C, 1 h, 2) -10 deg C, 1 h, r.t., overnight;