(2S,4S,5S)-5-(benzyloxycarbonyl)amino-2-ethyl-4-hydroxy-7-methyloctanoic acid γ-lactone

Base Information

Chemical Name:(2S,4S,5S)-5-(benzyloxycarbonyl)amino-2-ethyl-4-hydroxy-7-methyloctanoic acid γ-lactone
CAS No.:141713-85-1
Molecular Formula:C₁₉H₂₇NO₄
Molecular Weight:333.428
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5S)-5-(benzyloxycarbonyl)amino-2-ethyl-4-hydroxy-7-methyloctanoic acid γ-lactone

Chemical Property:

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Technology Process of (2S,4S,5S)-5-(benzyloxycarbonyl)amino-2-ethyl-4-hydroxy-7-methyloctanoic acid γ-lactone

There total 2 articles about (2S,4S,5S)-5-(benzyloxycarbonyl)amino-2-ethyl-4-hydroxy-7-methyloctanoic acid γ-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118741-15-4
(4S,5S)-5-((E)-2-Ethoxycarbonyl-but-1-enyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 141713-85-1
(2S,4S,5S)-5-(benzyloxycarbonyl)amino-2-ethyl-4-hydroxy-7-methyloctanoic acid γ-lactone

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄, nickel chloride hexahydrate / ethanol / 0.5 h / Ambient temperature

2: p-toluenesulfonic acid / methanol / 3 h / Ambient temperature

With sodium tetrahydroborate; toluene-4-sulfonic acid; nickel dichloride; In methanol; ethanol;
DOI:10.1248/cpb.40.364

Reference yield:

: (4S,5S)-5-(2-Ethoxycarbonyl-butyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 141713-85-1
(2S,4S,5S)-5-(benzyloxycarbonyl)amino-2-ethyl-4-hydroxy-7-methyloctanoic acid γ-lactone

: 141713-84-0
(2R,4S,5S)-5-(benzyloxycarbonyl)amino-2-ethyl-4-hydroxy-7-methyloctanoic acid γ-lactone

Guidance literature:: With toluene-4-sulfonic acid; In methanol; for 3h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1248/cpb.40.364