(1R)-2-(4-methylsulphonyloxyphenyl)<1-(2)H1>ethanol

Base Information

• Chemical Name: (1R)-2-(4-methylsulphonyloxyphenyl)<1-(2)H1>ethanol
• CAS No.: 74447-52-2
• Molecular Formula: C₉H₁₂O₄S
• Molecular Weight: 217.25
• Mol file: 74447-52-2.mol

Synonyms:

Chemical Property of (1R)-2-(4-methylsulphonyloxyphenyl)<1-(2)H1>ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-2-(4-methylsulphonyloxyphenyl)<1-(2)H1>ethanol

There total 7 articles about (1R)-2-(4-methylsulphonyloxyphenyl)<1-(2)H1>ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylsulphonyloxyphenylacetaldehyde (74447-37-3) → (1R)-2-(4-methylsulphonyloxyphenyl)<1-(2)H1>ethanol (74447-52-2)

Guidance literature:

With cyclopentanol-O-d1; liver alcohol dehydrogenase; NAD; In 1,4-dioxane; at 37 ℃; phosphate buffer (pH 7);

Reference yield:

4-benzyloxybenzyl alcohol (836-43-1) → (1R)-2-(4-methylsulphonyloxyphenyl)<1-(2)H1>ethanol (74447-52-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 3.1 g / thionyl chloride / diethyl ether / 2 h / Heating

2: 4.2 g / n-butyl-lithium / hexane; tetrahydrofuran / 1.) -23 deg C, 1.5 h, 2.) 0 deg C, 14 h

3: 3.6 g / mercuric oxide, mercuric chloride / acetonitrile / 6 h / Heating

4: 1.) Raney nickel, 2.) hydrogen / 2.) palladium on charcoal / 1.) ethanol, reflux, 15 - 20 min, 2.) methanol,

5: 2.5 g / triethylamine / CH₂Cl₂ / 0.17 h / 0 - 10 °C

6: 1.12 g / aq. hydrochloric acid / tetrahydrofuran / 0.67 h / 18 °C

7: 91 mg / <1-⁽²⁾H>cyclopentanol, NAD+, liver alcohol dehydrogenase / dioxane / 37 °C / phosphate buffer (pH 7)

With hydrogenchloride; n-butyllithium; thionyl chloride; cyclopentanol-O-d1; liver alcohol dehydrogenase; NAD; hydrogen; nickel; triethylamine; mercury dichloride; mercury(II) oxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; acetonitrile;

Reference yield:

2-(4-benzyloxyphenyl)-1,1-dimethoxyethane (74447-41-9) → (1R)-2-(4-methylsulphonyloxyphenyl)<1-(2)H1>ethanol (74447-52-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Raney nickel, 2.) hydrogen / 2.) palladium on charcoal / 1.) ethanol, reflux, 15 - 20 min, 2.) methanol,

2: 2.5 g / triethylamine / CH₂Cl₂ / 0.17 h / 0 - 10 °C

3: 1.12 g / aq. hydrochloric acid / tetrahydrofuran / 0.67 h / 18 °C

4: 91 mg / <1-⁽²⁾H>cyclopentanol, NAD+, liver alcohol dehydrogenase / dioxane / 37 °C / phosphate buffer (pH 7)

With hydrogenchloride; cyclopentanol-O-d1; liver alcohol dehydrogenase; NAD; hydrogen; nickel; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

upstream raw materials:

4-methylsulphonyloxyphenylacetaldehyde

4-benzyloxybenzyl alcohol

2-(4-hydroxyphenyl)-1,1-dimethoxyethane

1,1-dimethoxy-2-(4-methylsulphonyloxyphenyl)ethane