2-(6-{3-[bis-(2-hydroxy-ethyl)-amino]-propoxy}-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

Base Information

• Chemical Name: 2-(6-{3-[bis-(2-hydroxy-ethyl)-amino]-propoxy}-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide
• CAS No.: 1232234-05-7
• Molecular Formula: C₂₄H₂₆ClN₅O₄S
• Molecular Weight: 516.021
• Mol file: 1232234-05-7.mol

Synonyms:

Chemical Property of 2-(6-{3-[bis-(2-hydroxy-ethyl)-amino]-propoxy}-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-{3-[bis-(2-hydroxy-ethyl)-amino]-propoxy}-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

There total 8 articles about 2-(6-{3-[bis-(2-hydroxy-ethyl)-amino]-propoxy}-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-chloro-phenyl)-2-(6-hydroxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide (1232234-84-2) → 2-(6-{3-[bis-(2-hydroxy-ethyl)-amino]-propoxy}-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide (1232234-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

2: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 6 h / 100 °C

With potassium carbonate; caesium carbonate; potassium iodide; In N,N-dimethyl-formamide;

Reference yield:

2-(6-benzyloxy-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide (1232234-83-1) → 2-(6-{3-[bis-(2-hydroxy-ethyl)-amino]-propoxy}-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide (1232234-05-7)

Guidance literature:

Multi-step reaction with 3 steps

1: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

3: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 6 h / 100 °C

With boron dimethyl-trifluoro sulphide; potassium carbonate; caesium carbonate; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2-(2-amino-5-benzyloxy-phenylamino)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid ethyl ester (1232234-80-8) → 2-(6-{3-[bis-(2-hydroxy-ethyl)-amino]-propoxy}-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide (1232234-05-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: acetic acid / 1 h / 50 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 60 °C

2.2: pH ~ 3 - 4

3.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

6.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 6 h / 100 °C

With boron dimethyl-trifluoro sulphide; water; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-(3-chloro-phenyl)-2-(6-hydroxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

2-(6-benzyloxy-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid

2-(6-benzyloxy-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide

2-(2-amino-5-benzyloxy-phenylamino)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid ethyl ester