5-Bromo-2-methoxymethylaniline

Base Information

• Chemical Name: 5-Bromo-2-methoxymethylaniline
• CAS No.: 1598981-76-0
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.077
• Mol file: 1598981-76-0.mol

Synonyms:

Chemical Property of 5-Bromo-2-methoxymethylaniline

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-(methoxymethyl)aniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Bromo-2-methoxymethylaniline

There total 3 articles about 5-Bromo-2-methoxymethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-bromo-1-(methoxymethyl)-2-nitrobenzene (874959-52-1) → 5-bromo-2-(methoxymethyl)aniline (1598981-76-0)

Guidance literature:

With tin(II) chloride dihdyrate; In dichloromethane; ethyl acetate; at 20 ℃; for 20h;

Reference yield:

(4-bromo-2-nitrophenyl)methanol (22996-19-6) → 5-bromo-2-(methoxymethyl)aniline (1598981-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 h / 20 °C

2: tin(II) chloride dihdyrate / dichloromethane; ethyl acetate / 20 h / 20 °C

With tin(II) chloride dihdyrate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In dichloromethane; water; ethyl acetate;

Reference yield:

4-bromo-2-nitrobenzaldehyde (5551-12-2) → 5-bromo-2-(methoxymethyl)aniline (1598981-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol; water / 17.5 h / 0 °C

2: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 h / 20 °C

3: tin(II) chloride dihdyrate / dichloromethane; ethyl acetate / 20 h / 20 °C

With sodium tetrahydroborate; tin(II) chloride dihdyrate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In ethanol; dichloromethane; water; ethyl acetate;

upstream raw materials:

(4-bromo-2-nitrophenyl)methanol

4-bromo-1-(methoxymethyl)-2-nitrobenzene

4-bromo-2-nitrobenzaldehyde

Refernces