Ac-Leu-Asn--Ile-Val-OMe

Base Information

• Chemical Name: Ac-Leu-Asn--Ile-Val-OMe
• CAS No.: 127231-46-3
• Molecular Formula: C₃₉H₆₃N₇O₉
• Molecular Weight: 773.971
• Mol file: 127231-46-3.mol

Synonyms:

Chemical Property of Ac-Leu-Asn--Ile-Val-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ac-Leu-Asn--Ile-Val-OMe

There total 10 articles about Ac-Leu-Asn--Ile-Val-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-Amino-N1-((S)-1-benzyl-3-chloro-2-oxo-propyl)-succinamide → Ac-Leu-Asn--Ile-Val-OMe (127231-46-3,127306-17-6,137328-44-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) hydroxybenzotriazole (HOBt), EDCI, 2.) N-methylmorpholine (NMM) / 1.) DMF, 40 min, 2.) DMF, a) 0 deg C, 2 h, b) RT, overnight

2: 4 N HCl / dioxane / 1 h / Ambient temperature

3: triethylamine, DCM / dimethylformamide / 2 h / 0 - 20 °C

4: NaI, NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

5: NaBH₄ / methanol

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; sodium iodide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00099a008

Reference yield:

(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-N1-((S)-1-benzyl-3-chloro-2-oxo-propyl)-succinamide (137150-40-4) → Ac-Leu-Asn--Ile-Val-OMe (127231-46-3,127306-17-6,137328-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI, NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

2: NaBH₄ / methanol

With sodium tetrahydroborate; sodium hydrogencarbonate; sodium iodide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00099a008

Reference yield:

(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-N1-((S)-1-benzyl-3-chloro-2-oxo-propyl)-succinamide → Ac-Leu-Asn--Ile-Val-OMe (127231-46-3,127306-17-6,137328-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine, DCM / dimethylformamide / 2 h / 0 - 20 °C

2: NaI, NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

3: NaBH₄ / methanol

With sodium tetrahydroborate; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; sodium hydrogencarbonate; triethylamine; sodium iodide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00099a008

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

(3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate

(3S)-3-amino-1-chloro-4-phenyl-2-butanone hydrochloride

(3S)-<amino>-1-chloro-4-phenyl-2-butanone