3-methoxy-8-oxo-4,5,6,6a-tetrahydro-8H-7-oxa-benzo[4,5]cyclohepta[1,2,3-de]naphthalene-12-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide

Base Information

• Chemical Name: 3-methoxy-8-oxo-4,5,6,6a-tetrahydro-8H-7-oxa-benzo[4,5]cyclohepta[1,2,3-de]naphthalene-12-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide
• CAS No.: 916895-56-2
• Molecular Formula: C₂₈H₂₇NO₄
• Molecular Weight: 441.527
• Mol file: 916895-56-2.mol

Synonyms:

Chemical Property of 3-methoxy-8-oxo-4,5,6,6a-tetrahydro-8H-7-oxa-benzo[4,5]cyclohepta[1,2,3-de]naphthalene-12-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-8-oxo-4,5,6,6a-tetrahydro-8H-7-oxa-benzo[4,5]cyclohepta[1,2,3-de]naphthalene-12-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide

There total 1 articles about 3-methoxy-8-oxo-4,5,6,6a-tetrahydro-8H-7-oxa-benzo[4,5]cyclohepta[1,2,3-de]naphthalene-12-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(8-hydroxy-4-methoxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-N-(1-methyl-1-phenyl-ethyl)-isophthalamic acid → 3-methoxy-8-oxo-4,5,6,6a-tetrahydro-8H-7-oxa-benzo[4,5]cyclohepta[1,2,3-de]naphthalene-12-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide (916895-56-2)

Guidance literature:

With dmap; 4-(dimethylamino)pyridine hydrochloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; for 2h; Heating;

DOI:10.1021/ol062428u

Reference yield:

3-methoxy-8-oxo-4,5,6,6a-tetrahydro-8H-7-oxa-benzo[4,5]cyclohepta[1,2,3-de]naphthalene-12-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide (916895-56-2) → 2-(8-hydroxy-4-methoxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-N-(1-methyl-1-phenyl-ethyl)-isophthalamic acid

Guidance literature:

With lithium hydroxide; In methanol; water; for 16h;

DOI:10.1021/ol062428u

Reference yield:

3-methoxy-8-oxo-4,5,6,6a-tetrahydro-8H-7-oxa-benzo[4,5]cyclohepta[1,2,3-de]naphthalene-12-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide (916895-56-2) → allyl-2-(8-hydroxy-4-methoxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-((2-phenylpropan-2-yl)carbamoyl)benzoate

Guidance literature:

Multi-step reaction with 2 steps

1: LiOH / methanol; H₂O / 16 h

2: 52 mg / potassium carbonate / dimethylformamide / 1 h

With lithium hydroxide; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/ol062428u