N--(S)-prolin-benzylester

Base Information

Chemical Name:N--(S)-prolin-benzylester
CAS No.:76847-30-8
Molecular Formula:C₃₀H₃₅N₃O₆
Molecular Weight:533.624
Hs Code.:

N-<N-tert-Butoxycarbonyl-3-(4-cyanmethylphenoxy)-(2S,3S)-prolyl>-(S)-prolin-benzylester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N--(S)-prolin-benzylester

Chemical Property:

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Technology Process of N--(S)-prolin-benzylester

There total 7 articles about N--(S)-prolin-benzylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 84426-16-4
N-tert-Butoxycarbonyl-trans-3-<4-(cyanmethyl)phenoxy>prolin

: 41324-66-7
H-Pro-OBzl

: 76847-30-8
N--(S)-prolin-benzylester

: 76847-31-9
N--(S)-prolin-benzylester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; 1) -10 deg C, 1h, 2) room temp., 2h;
DOI:10.1002/jlac.198219821206

Reference yield:

: 691-64-5
di-tert-butyl oxalate

: 76847-30-8
N--(S)-prolin-benzylester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 1N NaOH / dioxane; H₂O / 3 h / Ambient temperature

2: 48 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 1) -10 deg C, 1h, 2) room temp., 2h

With sodium hydroxide; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1002/jlac.198219821206

Reference yield:

: 14191-95-8
4-cyanomethylphenol

: 76847-30-8
N--(S)-prolin-benzylester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Na, / 1) C₂H₅OH, 2) DMF, 16h, room temp.

2: 93 percent / 1N NaOH / dioxane; H₂O / 0.5 h

3: dimethylaminborane / acetic acid / 1 h / Ambient temperature

4: 90 percent / 1N NaOH / dioxane; H₂O / 3 h / Ambient temperature

5: 48 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 1) -10 deg C, 1h, 2) room temp., 2h

With sodium hydroxide; dimethylamine borane; sodium; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water; acetic acid;
DOI:10.1002/jlac.198219821206