N-[2-(2-Amino-1-hydroxyethyl)phenyl]methanesulfonamide

Base Information

• Chemical Name: N-[2-(2-Amino-1-hydroxyethyl)phenyl]methanesulfonamide
• CAS No.: 785712-43-8
• Molecular Formula: C₉H₁₄N₂O₃S
• Molecular Weight: 230.288
• DSSTox Substance ID: DTXSID601208069
• Mol file: 785712-43-8.mol

Synonyms:N-[2-(2-Amino-1-hydroxyethyl)phenyl]methanesulfonamide;DTXSID601208069;785712-43-8

Chemical Property of N-[2-(2-Amino-1-hydroxyethyl)phenyl]methanesulfonamide

Chemical Property:

• XLogP3: -0.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 230.07251349
• Heavy Atom Count: 15
• Complexity: 286

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CS(=O)(=O)NC1=CC=CC=C1C(CN)O

Technology Process of N-[2-(2-Amino-1-hydroxyethyl)phenyl]methanesulfonamide

There total 5 articles about N-[2-(2-Amino-1-hydroxyethyl)phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-(1-hydroxy-2-nitro-ethyl)-phenyl]-methanesulfonamide → N-[2-(2-Amino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide (785712-43-8)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole / CH₂Cl₂

2: H₂ / Raney nickel / methanol

3: Bu₄NF / tetrahydrofuran

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; nickel; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.11.041

Reference yield:

N-[2-(2-nitro-1-triethylsilanyloxy-ethyl)-phenyl]-methanesulfonamide → N-[2-(2-Amino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide (785712-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney nickel / methanol

2: Bu₄NF / tetrahydrofuran

With tetrabutyl ammonium fluoride; hydrogen; nickel; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2006.11.041

Reference yield:

N-(2-formylphenyl)methanesulfonamide (94532-99-7) → N-[2-(2-Amino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide (785712-43-8)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. AcOH; NaOH / ethanol

2: imidazole / CH₂Cl₂

3: H₂ / Raney nickel / methanol

4: Bu₄NF / tetrahydrofuran

With 1H-imidazole; sodium hydroxide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.11.041

upstream raw materials:

2'-(Aminoacetyl)-methansulfonanilid-hydrochlorid

N-(2-formylphenyl)methanesulfonamide