trans-2-(3,4,5-trimethoxyphenyl)benzocyclobutyl acetate

Base Information

Chemical Name:trans-2-(3,4,5-trimethoxyphenyl)benzocyclobutyl acetate
CAS No.:107377-38-8
Molecular Formula:C₂₀H₂₀O₇
Molecular Weight:372.375
Hs Code.:

Synonyms:

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Chemical Property of trans-2-(3,4,5-trimethoxyphenyl)benzocyclobutyl acetate

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Technology Process of trans-2-(3,4,5-trimethoxyphenyl)benzocyclobutyl acetate

There total 15 articles about trans-2-(3,4,5-trimethoxyphenyl)benzocyclobutyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 546-67-8
lead(IV) tetraacetate

: 94671-22-4
trans-5,6-dihydro-6-(3,4,5-trimethoxyphenyl)cyclobuta(f)-1,3-benzodioxolecarboxylic acid

: 107377-38-8,115118-10-0,130322-35-9
trans-2-(3,4,5-trimethoxyphenyl)benzocyclobutyl acetate

Guidance literature:: With acetic acid; In dimethyl sulfoxide; at 18 ℃; for 1h;
DOI:10.1021/jo00251a003

Reference yield:

: 15930-53-7
6-bromo-3,4-methylenedioxybenzaldehyde

: 107377-38-8,115118-10-0,130322-35-9
trans-2-(3,4,5-trimethoxyphenyl)benzocyclobutyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / ammonium acetate / Heating

3: 95 percent / NaOMe / methanol

4: 77 percent / various solvent(s) / 140 °C / Heating; in DMA

5: 48 percent / LDA / tetrahydrofuran / -30 °C

6: 72 percent / 10percent aqueous KOH, H₂O₂ / methanol / 0.33 h / 45 °C

7: tetrahydrofuran; acetic acid / 2 h / 20 °C

With ammonium acetate; potassium hydroxide; dihydrogen peroxide; sodium methylate; lithium diisopropyl amide; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1016/S0040-4039(00)85200-4

Reference yield:

: 107377-30-0
3-(6-Bromo-benzo[1,3]dioxol-5-yl)-3-(3,4,5-trimethoxy-phenyl)-propionic acid ethyl ester

: 107377-38-8,115118-10-0,130322-35-9
trans-2-(3,4,5-trimethoxyphenyl)benzocyclobutyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / sodium amide, NH₃ (liquid) / tetrahydrofuran / 0.17 h / -78 °C

2: 85 percent / 50percent aq. KOH / dimethylsulfoxide / 1 h / 25 °C

3: 76 percent / acetic acid / dimethylsulfoxide / 1 h / 18 °C

With potassium hydroxide; ammonia; sodium amide; acetic acid; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jo00251a003