Technology Process of 2-chloro-N-(2-methoxyphenyl)-4-((4-nitrophenyl)thio)benzamide
There total 4 articles about 2-chloro-N-(2-methoxyphenyl)-4-((4-nitrophenyl)thio)benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-chloro-4-((4-nitrophenyl)thio)benzoic acid;
With
thionyl chloride;
In
N,N-dimethyl-formamide; benzene;
at 80 ℃;
for 2h;
2-methoxy-phenylamine;
With
triethylamine;
In
N,N-dimethyl-formamide; benzene;
at 80 ℃;
for 5h;
DOI:10.1021/ml300037k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hydroxide / tetrahydrofuran; methanol; water / 5 h / 20 °C
2.1: thionyl chloride / N,N-dimethyl-formamide; benzene / 2 h / 80 °C
2.2: 5 h / 80 °C
With
thionyl chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ml300037k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere
1.2: 6 h / 100 °C
2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 5 h / 20 °C
3.1: thionyl chloride / N,N-dimethyl-formamide; benzene / 2 h / 80 °C
3.2: 5 h / 80 °C
With
copper(l) iodide; thionyl chloride; potassium carbonate; lithium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ml300037k
