3S-methyl-5-oxo-1-(1R-phenylethyl)-3-pyrrolidinecarboxamide

Base Information

Chemical Name:3S-methyl-5-oxo-1-(1R-phenylethyl)-3-pyrrolidinecarboxamide
CAS No.:146512-07-4
Molecular Formula:C₁₄H₁₈N₂O₂
Molecular Weight:246.309
Hs Code.:

Synonyms:

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Chemical Property of 3S-methyl-5-oxo-1-(1R-phenylethyl)-3-pyrrolidinecarboxamide

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Technology Process of 3S-methyl-5-oxo-1-(1R-phenylethyl)-3-pyrrolidinecarboxamide

There total 4 articles about 3S-methyl-5-oxo-1-(1R-phenylethyl)-3-pyrrolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4S-methyl-1-(1R-phenylethyl)-4-<1-<(phenylmethoxy)imino>ethyl>-2-pyrrolidinone

: 146512-07-4
3S-methyl-5-oxo-1-(1R-phenylethyl)-3-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / H₂, conc. hydrochloric acid / 20percent palladium on carbon / methanol / 0.33 h

2: 87 percent / sodium bisulfide / ethanol; H₂O / 3 h / 100 °C

3: 91 percent / sodium hypobromite, sodium bromide, 50percent aq. NaOH / 4 h / Ambient temperature

4: oxalyl chloride / CH₂Cl₂ / 2 h / Ambient temperature

5: ammonium hydroxide / tetrahydrofuran / 18 h / Ambient temperature

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; sodium hydrogensulfide; sodium hypobromide; oxalyl dichloride; hydrogen; sodium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1002/jhet.5570290612

Reference yield:

: (S)-3-Methyl-5-oxo-1-((R)-1-phenyl-ethyl)-pyrrolidine-3-carbonyl chloride

: 146512-07-4
3S-methyl-5-oxo-1-(1R-phenylethyl)-3-pyrrolidinecarboxamide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; for 18h; Yield given; Ambient temperature;
DOI:10.1002/jhet.5570290612

Reference yield:

: 146511-99-1
4S-acetyl-4-methyl-1-(1R-phenylethyl)-2-pyrrolidinone

: 146512-07-4
3S-methyl-5-oxo-1-(1R-phenylethyl)-3-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / sodium hypobromite, sodium bromide, 50percent aq. NaOH / 4 h / Ambient temperature

2: oxalyl chloride / CH₂Cl₂ / 2 h / Ambient temperature

3: ammonium hydroxide / tetrahydrofuran / 18 h / Ambient temperature

With ammonium hydroxide; sodium hydroxide; sodium hypobromide; oxalyl dichloride; sodium bromide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/jhet.5570290612