Technology Process of ((3R,3aS,7aR)-1,6-Dibenzyl-7-oxo-octahydro-pyrrolo[2,3-c]pyridin-3-yl)-acetaldehyde
There total 11 articles about ((3R,3aS,7aR)-1,6-Dibenzyl-7-oxo-octahydro-pyrrolo[2,3-c]pyridin-3-yl)-acetaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) potassium trimethylsilanolate / 1.) THF, room temp., 2 h, 2.) CH2Cl2, 0 deg C
2: DMAP / CH2Cl2 / 2 h
3: 1,2-dichloro-benzene / 1.5 h / 320 °C
4: TsOH / methanol / 3 h / Ambient temperature
5: 1.) oxalyl chloride, DMSO, 2.) Et3N / CH2Cl2 / 1.) -78 deg C, 30 min, 2.) -78 deg C to room temp., 30 min
With
dmap; oxalyl dichloride; potassium trimethylsilonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
methanol; dichloromethane; 1,2-dichloro-benzene;
DOI:10.1021/jo00070a035
- Guidance literature:
-
Multi-step reaction with 4 steps
1: DMAP / CH2Cl2 / 2 h
2: 1,2-dichloro-benzene / 1.5 h / 320 °C
3: TsOH / methanol / 3 h / Ambient temperature
4: 1.) oxalyl chloride, DMSO, 2.) Et3N / CH2Cl2 / 1.) -78 deg C, 30 min, 2.) -78 deg C to room temp., 30 min
With
dmap; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
methanol; dichloromethane; 1,2-dichloro-benzene;
DOI:10.1021/jo00070a035
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
1.) -78 deg C, 30 min, 2.) -78 deg C to room temp., 30 min;
DOI:10.1021/jo00070a035
