Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Base Information

Chemical Name:Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester
CAS No.:97626-12-5
Molecular Formula:C₄₈H₄₇ClN₃O₁₂P
Molecular Weight:924.341
Hs Code.:

Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

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Chemical Property of Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

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Technology Process of Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

There total 9 articles about Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 97626-12-5
Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: p-toluenesulfonic acid monohydrate / CHCl₃ / 0.17 h / 0 °C

2: pyridine / 1.5 h / 0 °C

3: triethylamine hydrogen fluoride (TEAHF) / dioxane; tetrahydrofuran / Ambient temperature

4: pyridine / 1.5 h / Ambient temperature

5: 2.) 1-methylimidazole / 1.) dioxane, 1.5 h, 2.) dioxane, RT, 1 h

6: pyridine, triethylamine, H₂O / 0.5 h

With pyridine; 1-methyl-1H-imidazole; water; toluene-4-sulfonic acid; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; 1,4-dioxane; chloroform;

Reference yield:

: 90742-20-4
2'-O-tetrahydropyranyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

: 97626-12-5
Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 1.5 h / 0 °C

2: triethylamine hydrogen fluoride (TEAHF) / dioxane; tetrahydrofuran / Ambient temperature

3: pyridine / 1.5 h / Ambient temperature

4: 2.) 1-methylimidazole / 1.) dioxane, 1.5 h, 2.) dioxane, RT, 1 h

5: pyridine, triethylamine, H₂O / 0.5 h

With pyridine; 1-methyl-1H-imidazole; water; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 87138-60-1
4-N-benzoyl-2'-O-tetrahydropyranyl-3,5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

: 97626-12-5
Phosphoric acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine hydrogen fluoride (TEAHF) / dioxane; tetrahydrofuran / Ambient temperature

2: pyridine / 1.5 h / Ambient temperature

3: 2.) 1-methylimidazole / 1.) dioxane, 1.5 h, 2.) dioxane, RT, 1 h

4: pyridine, triethylamine, H₂O / 0.5 h

With pyridine; 1-methyl-1H-imidazole; water; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; 1,4-dioxane;