5-(acetyloxy)-3-(4-fluorophenyl)pentyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

Chemical Name:5-(acetyloxy)-3-(4-fluorophenyl)pentyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:1263799-46-7
Molecular Formula:C₂₃H₂₄F₄O₅
Molecular Weight:456.434
Hs Code.:

Synonyms:

Suppliers and Price of 5-(acetyloxy)-3-(4-fluorophenyl)pentyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(acetyloxy)-3-(4-fluorophenyl)pentyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(acetyloxy)-3-(4-fluorophenyl)pentyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 13 articles about 5-(acetyloxy)-3-(4-fluorophenyl)pentyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1263799-46-7
5-(acetyloxy)-3-(4-fluorophenyl)pentyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: piperidine / 72 h / 20 °C

1.2: 2 h / Reflux

2.1: sodium hydroxide / ethanol; water / 1 h / Reflux

2.2: pH 1

3.1: sulfuric acid / 3 h / Reflux

4.1: lithium aluminium tetrahydride / diethyl ether / 14 h / 20 °C / Inert atmosphere

5.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

6.1: AK lipase; water / acetonitrile / 11 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

7.1: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

With piperidine; dmap; lithium aluminium tetrahydride; AK lipase; sulfuric acid; water; triethylamine; sodium hydroxide; In diethyl ether; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo101962v

Reference yield:

: 3449-63-6
3-(4-fluorophenyl)pentan-1,5-dioic acid

: 1263799-46-7
5-(acetyloxy)-3-(4-fluorophenyl)pentyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 3 h / Reflux

2: lithium aluminium tetrahydride / diethyl ether / 14 h / 20 °C / Inert atmosphere

3: dmap; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

4: AK lipase; water / acetonitrile / 11 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

5: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; AK lipase; sulfuric acid; water; triethylamine; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jo101962v

Reference yield:

: 125080-12-8,125110-05-6,122930-33-0
ethyl 4-fluorobenzalacetoacetate

: 1263799-46-7
5-(acetyloxy)-3-(4-fluorophenyl)pentyl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / ethanol; water / 1 h / Reflux

1.2: pH 1

2.1: sulfuric acid / 3 h / Reflux

3.1: lithium aluminium tetrahydride / diethyl ether / 14 h / 20 °C / Inert atmosphere

4.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

5.1: AK lipase; water / acetonitrile / 11 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

6.1: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; AK lipase; sulfuric acid; water; triethylamine; sodium hydroxide; In diethyl ether; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo101962v