C₁₈H₁₄N₆O

Base Information

• Chemical Name: C₁₈H₁₄N₆O
• CAS No.: 1264926-30-8
• Molecular Formula: C₁₈H₁₄N₆O
• Molecular Weight: 330.349
• Mol file: 1264926-30-8.mol

Synonyms:

Chemical Property of C₁₈H₁₄N₆O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₄N₆O

There total 9 articles about C₁₈H₁₄N₆O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H8N2O3 → C18H14N6O (1264926-30-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide

2.1: lithium hydroxide / methanol / 90 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine

3.2: 160 °C

4.1: trifluoroacetic acid / 160 °C / Microwave irradiation

5.1: acetyl chloride / ethanol

With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; acetyl chloride; HATU; trifluoroacetic acid; lithium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2020.127279

Reference yield:

C11H9ClN2O → C18H14N6O (1264926-30-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide; 1-methyl-pyrrolidin-2-one / 20 °C

2.1: sulfuric acid / 100 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide

4.1: lithium hydroxide / methanol / 90 °C

5.1: HATU; N-ethyl-N,N-diisopropylamine

5.2: 160 °C

6.1: trifluoroacetic acid / 160 °C / Microwave irradiation

7.1: acetyl chloride / ethanol

With 1,4-diaza-bicyclo[2.2.2]octane; sulfuric acid; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; acetyl chloride; HATU; trifluoroacetic acid; lithium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2020.127279

Reference yield:

C25H20N2O3 → C18H14N6O (1264926-30-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hydroxide / methanol / 90 °C

2.1: HATU; N-ethyl-N,N-diisopropylamine

2.2: 160 °C

3.1: trifluoroacetic acid / 160 °C / Microwave irradiation

4.1: acetyl chloride / ethanol

With N-ethyl-N,N-diisopropylamine; acetyl chloride; HATU; trifluoroacetic acid; lithium hydroxide; In methanol; ethanol;

DOI:10.1016/j.bmcl.2020.127279

upstream raw materials:

phenylboronic acid

5-Methoxy-6-phenyl-pyrimidine-4-carbonitrile