Technology Process of 2-(4-(3-(prop-2-yn-1-yloxy)propyl)benzyl)piperidine hydrochloride
There total 6 articles about 2-(4-(3-(prop-2-yn-1-yloxy)propyl)benzyl)piperidine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 25 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jm400898x
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: iodine; acetic acid; sulfuric acid; sodium iodate / 20 h / 70 °C / Inert atmosphere
1.2: 2 h / Inert atmosphere
2.1: sodium hydroxide / 1,4-dioxane; water / 3 h / 0 - 25 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: piperidine; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 90 °C / Inert atmosphere
4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 10 h / Inert atmosphere
5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
5.2: 3 h / Inert atmosphere
6.1: hydrogenchloride / 1,4-dioxane / 3 h / 25 °C / Inert atmosphere
With
piperidine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium iodate; sulfuric acid; 10 wt% Pd(OH)2 on carbon; hydrogen; iodine; sodium hydride; acetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm400898x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 10 h / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
2.2: 3 h / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane / 3 h / 25 °C / Inert atmosphere
With
hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm400898x
