Technology Process of C21H21NO2
There total 4 articles about C21H21NO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: phosphorus tribromide / diethyl ether / 0 °C
2.1: sodium hydride / tetrahydrofuran / 1 h
2.2: 12 h
3.1: ethylmagnesium bromide / tetrahydrofuran / 1 h / 20 °C
3.2: 3 h / 20 °C
With
ethylmagnesium bromide; phosphorus tribromide; sodium hydride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/jo1024267
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 12 h / 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
3.1: phosphorus tribromide / diethyl ether / 0 °C
4.1: sodium hydride / tetrahydrofuran / 1 h
4.2: 12 h
5.1: ethylmagnesium bromide / tetrahydrofuran / 1 h / 20 °C
5.2: 3 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethylmagnesium bromide; tetrabutyl ammonium fluoride; phosphorus tribromide; sodium hydride; triethylamine;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/jo1024267
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
2.1: phosphorus tribromide / diethyl ether / 0 °C
3.1: sodium hydride / tetrahydrofuran / 1 h
3.2: 12 h
4.1: ethylmagnesium bromide / tetrahydrofuran / 1 h / 20 °C
4.2: 3 h / 20 °C
With
ethylmagnesium bromide; tetrabutyl ammonium fluoride; phosphorus tribromide; sodium hydride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/jo1024267
