((3R,5S,6R)-4-Benzyloxycarbonylamino-3-{(2R,3R)-3-benzyloxycarbonylamino-6-[(S)-1-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl]-tetrahydro-pyran-2-yloxy}-2,5-dihydroxy-6-methoxy-cyclohexyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:((3R,5S,6R)-4-Benzyloxycarbonylamino-3-{(2R,3R)-3-benzyloxycarbonylamino-6-[(S)-1-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl]-tetrahydro-pyran-2-yloxy}-2,5-dihydroxy-6-methoxy-cyclohexyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester
CAS No.:79198-79-1
Molecular Formula:C₃₇H₄₆Cl₆N₄O₁₃
Molecular Weight:967.509
Hs Code.:

((3R,5S,6R)-4-Benzyloxycarbonylamino-3-{(2R,3R)-3-benzyloxycarbonylamino-6-[(S)-1-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl]-tetrahydro-pyran-2-yloxy}-2,5-dihydroxy-6-methoxy-cyclohexyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of ((3R,5S,6R)-4-Benzyloxycarbonylamino-3-{(2R,3R)-3-benzyloxycarbonylamino-6-[(S)-1-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl]-tetrahydro-pyran-2-yloxy}-2,5-dihydroxy-6-methoxy-cyclohexyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

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Technology Process of ((3R,5S,6R)-4-Benzyloxycarbonylamino-3-{(2R,3R)-3-benzyloxycarbonylamino-6-[(S)-1-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl]-tetrahydro-pyran-2-yloxy}-2,5-dihydroxy-6-methoxy-cyclohexyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

There total 1 articles about ((3R,5S,6R)-4-Benzyloxycarbonylamino-3-{(2R,3R)-3-benzyloxycarbonylamino-6-[(S)-1-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl]-tetrahydro-pyran-2-yloxy}-2,5-dihydroxy-6-methoxy-cyclohexyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78740-84-8
N-(2,2,2-trichloroethoxycarbonyloxy)phthalimide

: 71624-53-8
1,2'-di-N-benzyloxycarbonylfortimicin B

: 79198-79-1
((3R,5S,6R)-4-Benzyloxycarbonylamino-3-{(2R,3R)-3-benzyloxycarbonylamino-6-[(S)-1-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl]-tetrahydro-pyran-2-yloxy}-2,5-dihydroxy-6-methoxy-cyclohexyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: In chloroform; for 18h; Ambient temperature;
DOI:10.1016/S0040-4020(01)92446-9

Reference yield:

: 79198-79-1
((3R,5S,6R)-4-Benzyloxycarbonylamino-3-{(2R,3R)-3-benzyloxycarbonylamino-6-[(S)-1-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl]-tetrahydro-pyran-2-yloxy}-2,5-dihydroxy-6-methoxy-cyclohexyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

: 66768-12-5,72275-67-3,73285-04-8,78781-03-0,78853-70-0,82731-19-9
6'-epi-fortimicin A disulfate

Guidance literature:: Multi-step reaction with 10 steps

1: 8.5 g / NaHCO₃ / methanol; H₂O / 1.5 h / Heating

2: 8.35 g / Zn / acetic acid / 18 h / Ambient temperature

3: N-chlorosuccinimide / CH₂Cl₂ / 1 h / Ambient temperature

4: 2.5 g / 1percent triethylenediamine / ethanol / 1.3 h / Ambient temperature

5: 2.73 g / NaBH₄ / methanol; H₂O / 2 h / 0 °C

6: 8.1 g / 6N KOH / ethanol / 80 °C

7: 13.8 g / methanol; H₂O / 1.) 0 deg C, 3 h; 2.) room temp., 18 h

8: 11.8 g / tetrahydrofuran / 24 h / Ambient temperature

9: 1.70 g / 0.2 N HCl, H₂ / Pd/C / methanol / 4 h / 2280 Torr

10: anion exchange resin (A₆₁-X₂)

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; N-chloro-succinimide; anion exchange resin (A₆₁-X₂); hydrogen; sodium hydrogencarbonate; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4020(01)92446-9

Reference yield:

: 79198-79-1
((3R,5S,6R)-4-Benzyloxycarbonylamino-3-{(2R,3R)-3-benzyloxycarbonylamino-6-[(S)-1-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl]-tetrahydro-pyran-2-yloxy}-2,5-dihydroxy-6-methoxy-cyclohexyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

: 67010-18-8,71564-66-4,71695-73-3,76420-54-7,76822-45-2,78738-61-1,78821-72-4,79703-13-2
6'-epi-fortimicin A

Guidance literature:: Multi-step reaction with 9 steps

1: 8.5 g / NaHCO₃ / methanol; H₂O / 1.5 h / Heating

2: 8.35 g / Zn / acetic acid / 18 h / Ambient temperature

3: N-chlorosuccinimide / CH₂Cl₂ / 1 h / Ambient temperature

4: 2.5 g / 1percent triethylenediamine / ethanol / 1.3 h / Ambient temperature

5: 2.73 g / NaBH₄ / methanol; H₂O / 2 h / 0 °C

6: 8.1 g / 6N KOH / ethanol / 80 °C

7: 13.8 g / methanol; H₂O / 1.) 0 deg C, 3 h; 2.) room temp., 18 h

8: 11.8 g / tetrahydrofuran / 24 h / Ambient temperature

9: 1.70 g / 0.2 N HCl, H₂ / Pd/C / methanol / 4 h / 2280 Torr

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; N-chloro-succinimide; hydrogen; sodium hydrogencarbonate; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4020(01)92446-9