Cbz-L-PheAib₄PhSerOH

Base Information

Chemical Name:Cbz-L-PheAib₄PhSerOH
CAS No.:1367370-61-3
Molecular Formula:C₄₂H₅₄N₆O₁₀
Molecular Weight:802.925
Hs Code.:

Synonyms:

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Chemical Property of Cbz-L-PheAib₄PhSerOH

Chemical Property:

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Technology Process of Cbz-L-PheAib₄PhSerOH

There total 5 articles about Cbz-L-PheAib₄PhSerOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1367370-56-6
Cbz-L-Phe-Aib₄-PhSer-OMe

: 1367370-61-3
Cbz-L-PheAib₄PhSerOH

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2cc00060a

Reference yield:

: 1187839-02-6
N₃(α-aminoisobutyric acid)₄OtBu

: 1367370-61-3
Cbz-L-PheAib₄PhSerOH

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium on activated charcoal; hydrogen / methanol

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / Inert atmosphere

4.2: 24 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With palladium on activated charcoal; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c2cc00060a

Reference yield:

: 1187839-07-1
Cbz(L-Phe)(α-aminoisobutyric acid₎₄OtBu

: 1367370-61-3
Cbz-L-PheAib₄PhSerOH

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2cc00060a