Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

Base Information

Chemical Name:Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester
CAS No.:1054645-74-7
Molecular Formula:C₄₅H₄₉N₄O₉PSi
Molecular Weight:848.965
Hs Code.:

Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

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Chemical Property of Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

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Technology Process of Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

There total 4 articles about Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890-38-0
2-deoxyinosine

: 1054645-74-7
Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Py

2: iPr₂EtN / CH₂Cl₂ / 1.5 h

3: 1H-tetrazole / acetonitrile

With pyridine; 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo951593c

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1054645-74-7
Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Py

2: iPr₂EtN / CH₂Cl₂ / 1.5 h

3: 1H-tetrazole / acetonitrile

With pyridine; 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo951593c

Reference yield:

: 175354-96-8
5′-O-[tert-butyl(diphenyl)silyl]-2′-deoxyinosine

: 1054645-74-7
Phosphorous acid allyl ester (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: iPr₂EtN / CH₂Cl₂ / 1.5 h

2: 1H-tetrazole / acetonitrile

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo951593c