benzyl 6-fluoro-2',4'-dioxospiro-8-carbamate

Base Information

Chemical Name:benzyl 6-fluoro-2',4'-dioxospiro-8-carbamate
CAS No.:95859-73-7
Molecular Formula:C₁₉H₁₅FN₂O₅S
Molecular Weight:402.403
Hs Code.:

benzyl 6-fluoro-2',4'-dioxospiro<chroman-4,5'-thiazolidine>-8-carbamate

Synonyms:

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Chemical Property of benzyl 6-fluoro-2',4'-dioxospiro-8-carbamate

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Technology Process of benzyl 6-fluoro-2',4'-dioxospiro-8-carbamate

There total 9 articles about benzyl 6-fluoro-2',4'-dioxospiro-8-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 95859-54-4,114623-84-6,114672-14-9
8-amino-6-fluorospiro-2',4'-dione

: 95859-73-7
benzyl 6-fluoro-2',4'-dioxospiro-8-carbamate

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1016/0223-5234(87)90297-2

Reference yield:

: 66892-34-0
6-fluoro-4-chromanone

: 95859-73-7
benzyl 6-fluoro-2',4'-dioxospiro-8-carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: potassium cyanide / 18-crown-6 / CH₂Cl₂ / 4 h / Ambient temperature

2: 76 percent / hydrogen chloride / 5 - 10 °C

3: 98 percent / 1N sulfuric acid / diethyl ether / 3.5 h / Ambient temperature

4: 95 percent / 18 h / -5 °C

5: 43 percent / acetone / 336 h / Heating

6: 97.5 percent / 37percent aq. hydrochloric acid / methanol / Heating

7: 96percent nitric acid / 0.08 h / -20 °C

8: 80 percent / 25percent aq. ammonia, NH₄Cl, Na₂S / ethanol; H₂O / 2.5 h / Heating

9: 22 percent / pyridine / Ambient temperature

With pyridine; hydrogenchloride; potassium cyanide; sodium sulfide; ammonium hydroxide; sulfuric acid; nitric acid; ammonium chloride; 18-crown-6 ether; In methanol; diethyl ether; ethanol; dichloromethane; water; acetone;
DOI:10.1016/0223-5234(87)90297-2

Reference yield:

: 74187-57-8
6-fluoro-2,3-dihydro-4-cyano-4-[(trimethylsilyl)oxy]-4H-benzopyran

: 95859-73-7
benzyl 6-fluoro-2',4'-dioxospiro-8-carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: 76 percent / hydrogen chloride / 5 - 10 °C

2: 98 percent / 1N sulfuric acid / diethyl ether / 3.5 h / Ambient temperature

3: 95 percent / 18 h / -5 °C

4: 43 percent / acetone / 336 h / Heating

5: 97.5 percent / 37percent aq. hydrochloric acid / methanol / Heating

6: 96percent nitric acid / 0.08 h / -20 °C

7: 80 percent / 25percent aq. ammonia, NH₄Cl, Na₂S / ethanol; H₂O / 2.5 h / Heating

8: 22 percent / pyridine / Ambient temperature

With pyridine; hydrogenchloride; sodium sulfide; ammonium hydroxide; sulfuric acid; nitric acid; ammonium chloride; In methanol; diethyl ether; ethanol; water; acetone;
DOI:10.1016/0223-5234(87)90297-2