benzhydryl 7--3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)ceph-3-em-4-carboxylate

Base Information

Chemical Name:benzhydryl 7--3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)ceph-3-em-4-carboxylate
CAS No.:62543-34-4
Molecular Formula:C₃₇H₃₈N₆O₆S₂
Molecular Weight:726.877
Hs Code.:

benzhydryl 7-<D-(-)-α-(tert-butyloxycarboxamido)-phenylacetamido>-3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)ceph-3-em-4-carboxylate

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Chemical Property of benzhydryl 7--3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)ceph-3-em-4-carboxylate

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Technology Process of benzhydryl 7--3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)ceph-3-em-4-carboxylate

There total 6 articles about benzhydryl 7--3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)ceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62543-14-0
benzhydryl 3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)-7-thienylacetamidoceph-3-em-4-carboxylate

: 62543-34-4
benzhydryl 7--3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)ceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) pyridine, phosphorus pentachloride; 2.) methanol / 1.) CH₂Cl₂, 10 deg C, 1 h; 2.) -20 deg C, 2 h

2: 1-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide metha-p-toluenesulfonate / tetrahydrofuran / 2 h / Ambient temperature

With pyridine; methanol; phosphorus pentachloride; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In tetrahydrofuran;
DOI:10.1248/cpb.28.2116

Reference yield:

: 33741-82-1
benzhydryl 3-formyl-7-thienylacetamidoceph-3-em-4-carboxylate

: 62543-34-4
benzhydryl 7--3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)ceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / dimethylsulfoxide / 0.5 h / Ambient temperature

2: 90 percent / DDQ / dioxane / 0.17 h / Ambient temperature; further reag., and time

3: 1.) pyridine, phosphorus pentachloride; 2.) methanol / 1.) CH₂Cl₂, 10 deg C, 1 h; 2.) -20 deg C, 2 h

4: 1-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide metha-p-toluenesulfonate / tetrahydrofuran / 2 h / Ambient temperature

With pyridine; methanol; phosphorus pentachloride; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;
DOI:10.1248/cpb.28.2116

Reference yield:

: 62543-12-8
benzhydryl 3-(4,4-dimethylaminothiocarbonylhydrazonomethyl)-7-thienylacetamidoceph-3-em-4-carboxylate

: 62543-34-4
benzhydryl 7--3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)ceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / DDQ / dioxane / 0.17 h / Ambient temperature; further reag., and time

2: 1.) pyridine, phosphorus pentachloride; 2.) methanol / 1.) CH₂Cl₂, 10 deg C, 1 h; 2.) -20 deg C, 2 h

3: 1-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide metha-p-toluenesulfonate / tetrahydrofuran / 2 h / Ambient temperature

With pyridine; methanol; phosphorus pentachloride; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1248/cpb.28.2116