5,7''-biflavone

Base Information

• Chemical Name: 5,7''-biflavone
• CAS No.: 1247006-93-4
• Molecular Formula: C₃₀H₁₈O₄
• Molecular Weight: 442.471
• Mol file: 1247006-93-4.mol

Synonyms:

Chemical Property of 5,7''-biflavone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,7''-biflavone

There total 3 articles about 5,7''-biflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

trifluoro-methanesulfonic acid 4-oxo-2-phenyl-4H-chromen-5-yl ester (920286-84-6) + 7-pinacolatoborylflavone (1247006-95-6) → 5,7''-biflavone (1247006-93-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In benzene; for 16h; Inert atmosphere; Reflux;

DOI:10.3987/COM-10-S(E)36

Reference yield:

7-bromo-2-phenyl-4H-1-benzopyran-4-one (1148-47-6) → 5,7''-biflavone (1247006-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate; triphenylphosphine / dimethyl sulfoxide / 6 h / 80 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / benzene / 16 h / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; triphenylphosphine; In dimethyl sulfoxide; benzene; 2: Suzuki coupling;

DOI:10.3987/COM-10-S(E)36

Reference yield:

5-Hydroxyflavone (491-78-1,66585-06-6) → 5,7''-biflavone (1247006-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / benzene / 16 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In benzene; 2: Suzuki coupling;

DOI:10.3987/COM-10-S(E)36

upstream raw materials:

trifluoro-methanesulfonic acid 4-oxo-2-phenyl-4H-chromen-5-yl ester

7-pinacolatoborylflavone

7-bromo-2-phenyl-4H-1-benzopyran-4-one

5-Hydroxyflavone