2-hydroxy-2-phenethylpentanedioic acid 5-[((S)-1-benzylcarbamoyl-2-methylpropyl)amide] 1-{[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenyl]amide}

Base Information

• Chemical Name: 2-hydroxy-2-phenethylpentanedioic acid 5-[((S)-1-benzylcarbamoyl-2-methylpropyl)amide] 1-{[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenyl]amide}
• CAS No.: 1187975-77-4
• Molecular Formula: C₄₂H₅₀FN₅O₇S
• Molecular Weight: 787.953
• Mol file: 1187975-77-4.mol

Synonyms:

Chemical Property of 2-hydroxy-2-phenethylpentanedioic acid 5-[((S)-1-benzylcarbamoyl-2-methylpropyl)amide] 1-{[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenyl]amide}

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-2-phenethylpentanedioic acid 5-[((S)-1-benzylcarbamoyl-2-methylpropyl)amide] 1-{[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenyl]amide}

There total 1 articles about 2-hydroxy-2-phenethylpentanedioic acid 5-[((S)-1-benzylcarbamoyl-2-methylpropyl)amide] 1-{[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenyl]amide} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(S)-2-amino-N-benzyl-3-methylbutyramide hydrochloride (1201901-59-8) + 5-oxo-2-phenethyltetrahydrofuran-2-carboxylic acid [3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonylmethylamino)phenyl]amide (1187975-73-0) → 2-hydroxy-2-phenethylpentanedioic acid 5-[((S)-1-benzylcarbamoyl-2-methylpropyl)amide] 1-{[3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonyl(methyl)amino)phenyl]amide} (1187975-77-4)

Guidance literature:

With 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 72h; Reflux;

DOI:10.1016/j.bmcl.2009.06.065

upstream raw materials:

(S)-2-amino-N-benzyl-3-methylbutyramide hydrochloride

5-oxo-2-phenethyltetrahydrofuran-2-carboxylic acid [3-[(R)-1-(4-fluorophenyl)ethylcarbamoyl]-5-(methanesulfonylmethylamino)phenyl]amide