Technology Process of 5α-androstane-3,12,17-trione
There total 8 articles about 5α-androstane-3,12,17-trione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
[Fe(II)(CF3SO3)2(N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)cyclohexane-trans-1,2-diamine)]; dihydrogen peroxide; acetic acid;
In
water; acetonitrile;
at 0 ℃;
for 0.45h;
Overall yield = 28 %Chromat.; regioselective reaction;
DOI:10.1002/adsc.201300923
- Guidance literature:
-
With
[((1S,2,S)-N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine)bis(triflate)iron]; dihydrogen peroxide; acetic acid;
In
water; acetonitrile;
at 0 ℃;
for 0.45h;
Reagent/catalyst;
Overall yield = 29 %; Overall yield = 34 %Chromat.; regioselective reaction;
DOI:10.1002/adsc.201300923
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridinium chlorochromate / dichloromethane / 0 - 20 °C
2: [Fe(II)(CF3SO3)2(N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)cyclohexane-trans-1,2-diamine)]; acetic acid; dihydrogen peroxide / acetonitrile; water / 0.45 h / 0 °C
With
[Fe(II)(CF3SO3)2(N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)cyclohexane-trans-1,2-diamine)]; dihydrogen peroxide; acetic acid; pyridinium chlorochromate;
In
dichloromethane; water; acetonitrile;
DOI:10.1002/adsc.201300923