N-{4-[(3-chloro-4-fluorophenyl)amino]quinazolin-6-yl}-3-isocyanopropanamide

Base Information

Chemical Name:N-{4-[(3-chloro-4-fluorophenyl)amino]quinazolin-6-yl}-3-isocyanopropanamide
CAS No.:1043522-37-7
Molecular Formula:C₁₈H₁₃ClFN₅O
Molecular Weight:369.786
Hs Code.:

Synonyms:

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Chemical Property of N-{4-[(3-chloro-4-fluorophenyl)amino]quinazolin-6-yl}-3-isocyanopropanamide

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Technology Process of N-{4-[(3-chloro-4-fluorophenyl)amino]quinazolin-6-yl}-3-isocyanopropanamide

There total 1 articles about N-{4-[(3-chloro-4-fluorophenyl)amino]quinazolin-6-yl}-3-isocyanopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1043521-97-6
N-{4-[(3-chloro-4-fluorophenyl)amino]quinazolin-6-yl}-N³-formyl alaninamide

: 1043522-37-7
N-{4-[(3-chloro-4-fluorophenyl)amino]quinazolin-6-yl}-3-isocyanopropanamide

Guidance literature:: With pyridine; p-toluenesulfonyl chloride; at 20 ℃; for 6h;
DOI:10.1039/b802021c

Reference yield: 90.0%

: 1043522-37-7
N-{4-[(3-chloro-4-fluorophenyl)amino]quinazolin-6-yl}-3-isocyanopropanamide

: 164114-69-6
Re(tris(2-mercaptoethyl)amine)(PMe₂Ph)

: 1043522-06-0
Re(tris(2-mercaptoethyl)amino)[N-[4-[(3-chloro-4-fluorophenyl)amino]quinazolin-6-yl]-3-isocyanopropanamide]

Guidance literature:: In chloroform; Re-complex dissolved in CHCl3, ligand added, refluxed for 1 h; washed with H2O, solvent evapd., silica gel column chromy. with CHCl3-MeOH- 25 % ammonia (80:60:0.2), recrystd. from CHCl3-MeOH (50:50); elem. anal.;
DOI:10.1039/b802021c