angustoline

Base Information

Chemical Name:angustoline
CAS No.:54713-51-8
Molecular Formula:C₂₀H₁₇N₃O₂
Molecular Weight:331.374
Hs Code.:

Synonyms:

Suppliers and Price of angustoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of angustoline

Chemical Property:

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Technology Process of angustoline

There total 7 articles about angustoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 40041-96-1
angustine

: 40041-95-0,54713-51-8
angustoline

Guidance literature:: With manganese(III) (Z)-2,2,6,6-tetramethyl-5-oxohept-3-en-3-olate; phenylsilane; oxygen; In ethanol; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2020.151757

Reference yield:

: 3430-23-7
3,5-dibromo-4-methyl-pyridine

: 40041-95-0,54713-51-8
angustoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

2.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / toluene / 2 h / 80 °C / Inert atmosphere

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine / ethanol / 4 h / 90 °C / Inert atmosphere

4.1: trichlorophosphate / 5 h / 80 °C / Inert atmosphere

4.2: 10 h / 60 °C / Inert atmosphere

5.1: manganese(III) (Z)-2,2,6,6-tetramethyl-5-oxohept-3-en-3-olate; phenylsilane; oxygen / ethanol / 2 h / 20 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; manganese(III) (Z)-2,2,6,6-tetramethyl-5-oxohept-3-en-3-olate; phenylsilane; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; oxygen; triethylamine; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; ethanol; toluene; 3.1: |Suzuki Coupling / 4.1: |Bischler-Napieralski Reaction;
DOI:10.1016/j.tetlet.2020.151757

Reference yield:

: C₈H₇Br₂NO₂

: 40041-95-0,54713-51-8
angustoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / toluene / 2 h / 80 °C / Inert atmosphere

2.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine / ethanol / 4 h / 90 °C / Inert atmosphere

3.1: trichlorophosphate / 5 h / 80 °C / Inert atmosphere

3.2: 10 h / 60 °C / Inert atmosphere

4.1: manganese(III) (Z)-2,2,6,6-tetramethyl-5-oxohept-3-en-3-olate; phenylsilane; oxygen / ethanol / 2 h / 20 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; manganese(III) (Z)-2,2,6,6-tetramethyl-5-oxohept-3-en-3-olate; phenylsilane; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; oxygen; triethylamine; trichlorophosphate; In ethanol; toluene; 2.1: |Suzuki Coupling / 3.1: |Bischler-Napieralski Reaction;
DOI:10.1016/j.tetlet.2020.151757