(6R,7S)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Base Information

Chemical Name:(6R,7S)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
CAS No.:78005-11-5
Molecular Formula:C₃₆H₄₀Cl₃N₃O₁₁
Molecular Weight:797.086
Hs Code.:

(6R,7S)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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Chemical Property of (6R,7S)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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Technology Process of (6R,7S)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

There total 7 articles about (6R,7S)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 542-32-5
(R,S)-2-aminoadipic acid

: 78005-11-5
(6R,7S)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 6 steps

1: concd H₂SO₄ / 0 °C

2: aq. KOH, aq. K₃PO₄ / acetone

3: dicyclohexylcarbodiimide (DCC), pyridine / CH₂Cl₂ / 25 °C

4: H₂ / 10percent Pd/C / ethyl acetate

5: (COCl)2, DMF / benzene / 10 °C

6: Et₃N, pyridine / CH₂Cl₂ / 0 °C

With pyridine; potassium hydroxide; potassium phosphate; oxalyl dichloride; sulfuric acid; hydrogen; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate; acetone; benzene;

Reference yield:

: 37051-24-4
2-tert-Butoxycarbonylamino-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

: 78005-11-5
(6R,7S)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethyl acetate

2: (COCl)2, DMF / benzene / 10 °C

3: Et₃N, pyridine / CH₂Cl₂ / 0 °C

With pyridine; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In dichloromethane; ethyl acetate; benzene;

Reference yield:

: 112295-37-1
δ-benzyl N-(tert-butyloxycarbonyl)-DL-aminoadipate

: 78005-11-5
(6R,7S)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide (DCC), pyridine / CH₂Cl₂ / 25 °C

2: H₂ / 10percent Pd/C / ethyl acetate

3: (COCl)2, DMF / benzene / 10 °C

4: Et₃N, pyridine / CH₂Cl₂ / 0 °C

With pyridine; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate; benzene;