C₂₃⁽¹⁴⁾CH₂₇FN₆O₃

Base Information

Chemical Name:C₂₃⁽¹⁴⁾CH₂₇FN₆O₃
CAS No.:1278406-27-1
Molecular Formula:C₂₄H₂₇FN₆O₃
Molecular Weight:468.504
Hs Code.:

C<sub>23</sub><sup>(14)</sup>CH<sub>27</sub>FN<sub>6</sub>O<sub>3</sub>

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Chemical Property of C₂₃⁽¹⁴⁾CH₂₇FN₆O₃

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Technology Process of C₂₃⁽¹⁴⁾CH₂₇FN₆O₃

There total 21 articles about C₂₃⁽¹⁴⁾CH₂₇FN₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1278406-22-6
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid

: 1278406-27-1
C₂₃⁽¹⁴⁾CH₂₇FN₆O₃

Guidance literature:: (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(N-methyl-N-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid; With sodium hydroxide; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; ammonium chloride; In water; acetonitrile; pH=< 5; Inert atmosphere;
DOI:10.1002/jlcr.1810

Reference yield:

: 1278406-11-3
methyl 2-[⁽¹⁴⁾C]-2-chloro-4-(4-fluorophenyl)-6-isopropylpyrimidine-5-carboxylate

: 1278406-27-1
C₂₃⁽¹⁴⁾CH₂₇FN₆O₃

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium t-butanolate / N,N-dimethyl-formamide / 2.08 h / 0 - 20 °C / Inert atmosphere

2.1: 1,4-diaza-bicyclo[2.2.2]octane / 6 h / 90 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene / 1.33 h / -78 - 0 °C / Inert atmosphere

3.2: 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane; water / 1.5 h / 0 - 5 °C / pH 9.15 / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 - -70 °C / Inert atmosphere

6.1: hydrogenchloride; water / acetonitrile / 6 h / 40 °C / Inert atmosphere

7.1: sodium hydroxide / acetonitrile / 4 h / 20 °C / Inert atmosphere

7.2: pH < 5 / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium bromide; sodium hydroxide; lithium hexamethyldisilazane; sodium t-butanolate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 5.1: Julia olefin synthesis;
DOI:10.1002/jlcr.1810

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 1278406-27-1
C₂₃⁽¹⁴⁾CH₂₇FN₆O₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid; copper(l) chloride / methanol / 114 h / 20 - 65 °C / Inert atmosphere

2.1: nitric acid / 1.17 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / pH 6 / Inert atmosphere

3.1: trichlorophosphate / 3 h / 100 °C / Inert atmosphere

4.1: sodium t-butanolate / N,N-dimethyl-formamide / 2.08 h / 0 - 20 °C / Inert atmosphere

5.1: 1,4-diaza-bicyclo[2.2.2]octane / 6 h / 90 °C / Inert atmosphere

6.1: diisobutylaluminium hydride / toluene / 1.33 h / -78 - 0 °C / Inert atmosphere

6.2: 0.5 h / 0 - 20 °C / Inert atmosphere

7.1: sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane; water / 1.5 h / 0 - 5 °C / pH 9.15 / Inert atmosphere

8.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 - -70 °C / Inert atmosphere

9.1: hydrogenchloride; water / acetonitrile / 6 h / 40 °C / Inert atmosphere

10.1: sodium hydroxide / acetonitrile / 4 h / 20 °C / Inert atmosphere

10.2: pH < 5 / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sulfuric acid; water; nitric acid; diisobutylaluminium hydride; sodium hydrogencarbonate; copper(l) chloride; potassium bromide; sodium hydroxide; lithium hexamethyldisilazane; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Biginelli reaction / 8.1: Julia olefin synthesis;
DOI:10.1002/jlcr.1810