2-nitro-3-methoxy-α-(oxo)benzenoacetic acid

Base Information

• Chemical Name: 2-nitro-3-methoxy-α-(oxo)benzenoacetic acid
• CAS No.: 82204-33-9
• Molecular Formula: C₁₀H₉NO₆
• Molecular Weight: 239.185
• Mol file: 82204-33-9.mol

Synonyms:

Chemical Property of 2-nitro-3-methoxy-α-(oxo)benzenoacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-nitro-3-methoxy-α-(oxo)benzenoacetic acid

There total 1 articles about 2-nitro-3-methoxy-α-(oxo)benzenoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-nitro-3-methoxy-α-(oxo)benzenoacetic acid (82204-33-9)

Guidance literature:

/BRN= 2659052/;

Reference yield: 91.0%

2-nitro-3-methoxy-α-(oxo)benzenoacetic acid (82204-33-9) → α-(hydroxyimino)-3-methoxy-2-nitrobenzeneacetic acid

Guidance literature:

In ethanol; water; for 20h;

Reference yield:

2-nitro-3-methoxy-α-(oxo)benzenoacetic acid (82204-33-9) → 1-benzenesulfonyl-4-keto-8-methoxy-1,2,2α,3,4,5-hexyhydrobenzindole

Guidance literature:

Multi-step reaction with 8 steps

1: 91 percent / ethanol; H₂O / 20 h

2: 100 percent / acetic anhydride

3: 83 percent / K₂CO₃ / dimethylformamide / 72 h

4: 80 percent / H₂ / 5percent Pd/C / dimethylformamide; ethyl acetate / 3 h / 78 °C / 2327.2 Torr

5: 1) borane-pyridine complex, HCl, 2) Et₃N / 1.) EtOH, 0 deg C, 2.) dichloromethane, RT, overnight

6: BuLi / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C

7: 1.) (CF₃CO)2O, 2.) BF₃*OEt₂ / 1.) dichloromethane, -18 deg C, 20 min, 2.) dichloromethane, RT, 1 h

8: 81 percent / Ra-Ni / CH₂Cl₂

With hydrogenchloride; n-butyllithium; borane pyridine; boron trifluoride diethyl etherate; hydrogen; acetic anhydride; potassium carbonate; triethylamine; trifluoroacetic anhydride; palladium on activated charcoal; Ra-Ni; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Downstream raw materials:

7-methoxy-1H-indole-2-carboxylic acid

(3-methoxy-2-nitro-phenyl)acetic acid

(3-methoxy-2-nitro-phenyl)-acetonitrile

ethyl 3-cyano-3-(3-methoxy-2-nitrobenzene)propionate