N-<(2S)-2-(3,4-dimethoxyphenyl)-2-isopropyl-5-<(3,4-dimethoxyphenethyl)methylamino>pentyl>-(1S)-10-camphorsulfonamide

Base Information

• Chemical Name: N-<(2S)-2-(3,4-dimethoxyphenyl)-2-isopropyl-5-<(3,4-dimethoxyphenethyl)methylamino>pentyl>-(1S)-10-camphorsulfonamide
• CAS No.: 107149-06-4
• Molecular Formula: C₃₇H₅₆N₂O₇S
• Molecular Weight: 672.927
• Mol file: 107149-06-4.mol

Synonyms:

Chemical Property of N-<(2S)-2-(3,4-dimethoxyphenyl)-2-isopropyl-5-<(3,4-dimethoxyphenethyl)methylamino>pentyl>-(1S)-10-camphorsulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(2S)-2-(3,4-dimethoxyphenyl)-2-isopropyl-5-<(3,4-dimethoxyphenethyl)methylamino>pentyl>-(1S)-10-camphorsulfonamide

There total 38 articles about N-<(2S)-2-(3,4-dimethoxyphenyl)-2-isopropyl-5-<(3,4-dimethoxyphenethyl)methylamino>pentyl>-(1S)-10-camphorsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methylhomoveratrylamine (3490-06-0) → N-<(2R)-2-(3,4-dimethoxyphenyl)-2-isopropyl-5-<(3,4-dimethoxyphenethyl)methylamino>pentyl>-(1S)-10-camphorsulfonamide (107149-06-4,107241-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 48 h / 80 °C

2: lithium aluminium hydride / tetrahydrofuran / 8 h / Heating

3: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00383a026

Reference yield:

N-methylhomoveratrylamine (3490-06-0) → N-<(2S)-2-(3,4-dimethoxyphenyl)-2-isopropyl-5-<(3,4-dimethoxyphenethyl)methylamino>pentyl>-(1S)-10-camphorsulfonamide (107149-06-4,107241-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 48 h / 80 °C

2: lithium aluminium hydride / tetrahydrofuran / 8 h / Heating

3: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00383a026

Reference yield:

N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide (13230-71-2) → N-<(2S)-2-(3,4-dimethoxyphenyl)-2-isopropyl-5-<(3,4-dimethoxyphenethyl)methylamino>pentyl>-(1S)-10-camphorsulfonamide (107149-06-4,107241-86-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 48 h / 80 °C

3: lithium aluminium hydride / tetrahydrofuran / 8 h / Heating

4: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00383a026

upstream raw materials:

(1S)-(+)-10-Camphorsulfonyl chloride

(R)-4-(3,4-Dimethoxy-phenyl)-N¹-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-isopropyl-N¹-methyl-pentane-1,5-diamine

N-methylhomoveratrylamine

N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide