C₁₈H₂₁NO₅

Base Information

• Chemical Name: C₁₈H₂₁NO₅
• CAS No.: 1435943-78-4
• Molecular Formula: C₁₈H₂₁NO₅
• Molecular Weight: 331.368
• Mol file: 1435943-78-4.mol

Synonyms:

Chemical Property of C₁₈H₂₁NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₁NO₅

There total 10 articles about C₁₈H₂₁NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H41NO6Si (1435943-76-2) → C18H21NO5 (1435943-78-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/asia.201200820

Reference yield:

5-Hexen-1-ol (821-41-0) → C18H21NO5 (1435943-78-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 2 h / -78 °C / Inert atmosphere

1.2: 0.08 h / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

4.1: dimethyl sulfoxide; trifluorormethanesulfonic acid / 5.5 h / 20 - 100 °C / Molecular sieve; Inert atmosphere

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; oxalyl dichloride; trifluorormethanesulfonic acid; sodium hydride; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 2.1: |Horner-Wadsworth-Emmons Olefination;

DOI:10.1002/asia.201200820

Reference yield:

MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) → C18H21NO5 (1435943-78-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; trifluoromethylsulfonic anhydride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; morpholine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluoromethylsulfonic anhydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/asia.201200820

upstream raw materials:

C₂₄H₂₇NO₃Si

C₃₄H₄₁NO₆Si

5-Hexen-1-ol

hex-5-en-1-al