tert-butyl 4-trifluoromethylphenylacetylenyl ether

Base Information

• Chemical Name: tert-butyl 4-trifluoromethylphenylacetylenyl ether
• CAS No.: 1436595-67-3
• Molecular Formula: C₁₃H₁₃F₃O
• Molecular Weight: 242.241
• Mol file: 1436595-67-3.mol

Synonyms:

Chemical Property of tert-butyl 4-trifluoromethylphenylacetylenyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-trifluoromethylphenylacetylenyl ether

There total 4 articles about tert-butyl 4-trifluoromethylphenylacetylenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N,N-diethyl-2-(4-(trifluoromethyl)phenyl)ethynesulfonamide (1436595-32-2) + potassium tert-butylate (865-47-4) → tert-butyl 4-trifluoromethylphenylacetylenyl ether (1436595-67-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1002/chem.201203015

Reference yield:

4-trifluoromethylphenylacetylene (705-31-7) → tert-butyl 4-trifluoromethylphenylacetylenyl ether (1436595-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: 0.33 h / -78 °C / Inert atmosphere

2.1: sodium periodate; ruthenium trichloride / water; acetonitrile; ethyl acetate / 0 °C

3.1: N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

With ruthenium trichloride; sodium periodate; n-butyllithium; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/chem.201203015

Reference yield:

N,N-diethyl-2-(4-(trifluoromethyl)phenyl)ethynesulfinamide (1436596-49-4) → tert-butyl 4-trifluoromethylphenylacetylenyl ether (1436595-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium periodate; ruthenium trichloride / water; acetonitrile; ethyl acetate / 0 °C

2: N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

With ruthenium trichloride; sodium periodate; In water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/chem.201203015

upstream raw materials:

N,N-diethyl-2-(4-(trifluoromethyl)phenyl)ethynesulfonamide

potassium tert-butylate

4-trifluoromethylphenylacetylene

N,N-diethyl-2-(4-(trifluoromethyl)phenyl)ethynesulfinamide

Downstream raw materials:

3-(tert-butoxy)-2,4-bis(4-(trifluoromethyl)phenyl)cyclobut-2-enone