N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Base Information

Chemical Name:N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
CAS No.:1025921-79-2
Molecular Formula:C₃₉H₃₉N₃O₆S
Molecular Weight:677.821
Hs Code.:

N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Chemical Property of N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Technology Process of N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

There total 11 articles about N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026309-63-6
N-(1-{4-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

: 1025921-79-2
N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: With tetrabutyl ammonium fluoride; In water;
DOI:10.1021/jo0003910

Reference yield:

: 441044-21-9
Benzoic acid (2R,3S,4R)-4-hydroxy-2-(2-hydroxy-ethyl)-5-methoxy-tetrahydro-furan-3-ylmethyl ester

: 1025921-79-2
N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: imidazole; acetic acid / dimethylformamide / 0.83 h

2.1: NaOH / methanol; H₂O

3.1: 21.90 g / 4-dimethylaminopyridine; triethylamine / tetrahydrofuran; methanol / 1.17 h

4.1: N-methyl-N-trimethylsilyltrifluoroacetamide / acetonitrile / 0.5 h

4.2: SnCl₄ / acetonitrile / 0.5 h / 20 °C

5.1: 5.432 g / NaOH / H₂O; methanol / 0.01 h / 20 °C

6.1: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -20 - 20 °C

7.1: 83 percent Spectr_. / dimethylformamide / 1.5 h / 20 °C

8.1: 86 percent / Bu₃SnH; azobisisobutyronitrile / toluene / 0.03 h / Heating

9.1: NaOH; water

10.1: triethylamine / tetrahydrofuran

11.1: Bu₄N⁽¹⁺⁾*F^(1-) / H₂O

With 1H-imidazole; dmap; sodium hydroxide; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; tetrabutyl ammonium fluoride; water; tri-n-butyl-tin hydride; acetic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: Vorbrueggen reaction / 6.1: Mitsunobu reaction / 8.1: Barton deoxygenation;
DOI:10.1021/jo0003910

Reference yield:

: Benzoic acid (2R,3S,4R)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-hydroxy-5-methoxy-tetrahydro-furan-3-ylmethyl ester

: 1025921-79-2
N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaOH / methanol; H₂O

2.1: 21.90 g / 4-dimethylaminopyridine; triethylamine / tetrahydrofuran; methanol / 1.17 h

3.1: N-methyl-N-trimethylsilyltrifluoroacetamide / acetonitrile / 0.5 h

3.2: SnCl₄ / acetonitrile / 0.5 h / 20 °C

4.1: 5.432 g / NaOH / H₂O; methanol / 0.01 h / 20 °C

5.1: diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -20 - 20 °C

6.1: 83 percent Spectr_. / dimethylformamide / 1.5 h / 20 °C

7.1: 86 percent / Bu₃SnH; azobisisobutyronitrile / toluene / 0.03 h / Heating

8.1: NaOH; water

9.1: triethylamine / tetrahydrofuran

10.1: Bu₄N⁽¹⁺⁾*F^(1-) / H₂O

With dmap; sodium hydroxide; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; tetrabutyl ammonium fluoride; water; tri-n-butyl-tin hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: Vorbrueggen reaction / 5.1: Mitsunobu reaction / 7.1: Barton deoxygenation;
DOI:10.1021/jo0003910