C₁₄H₈FNO₂

Base Information

Chemical Name:C₁₄H₈FNO₂
CAS No.:1309921-13-8
Molecular Formula:C₁₄H₈FNO₂
Molecular Weight:241.221
Hs Code.:

C<sub>14</sub>H<sub>8</sub>FNO<sub>2</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₄H₈FNO₂

Chemical Property:

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Technology Process of C₁₄H₈FNO₂

There total 9 articles about C₁₄H₈FNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309921-11-6
ethyl 3-cyano-4-(4-fluorophenyl)benzoate

: 1309921-13-8
C₁₄H₈FNO₂

Guidance literature:: With water; sodium hydroxide; In ethanol; for 3h;
DOI:10.1016/j.bmcl.2010.12.110

Reference yield:

: 946007-61-0
4-(benzyloxy)-3-cyanobenzoic acid

: 1309921-13-8
C₁₄H₈FNO₂

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr

4: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

6: water; sodium hydroxide / ethanol / 3 h

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium fluoride dihydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 5: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.110

Reference yield:

: 556836-18-1
4-benzyloxy-3-cyanobenzoyl chloride

: 1309921-13-8
C₁₄H₈FNO₂

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr

3: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

5: water; sodium hydroxide / ethanol / 3 h

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.110