C₅₆H₇₂N₈O₁₃P₂

Base Information

• Chemical Name: C₅₆H₇₂N₈O₁₃P₂
• CAS No.: 1427428-95-2
• Molecular Formula: C₅₆H₇₂N₈O₁₃P₂
• Molecular Weight: 1127.18
• Mol file: 1427428-95-2.mol

Synonyms:

Chemical Property of C₅₆H₇₂N₈O₁₃P₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₆H₇₂N₈O₁₃P₂

There total 4 articles about C₅₆H₇₂N₈O₁₃P₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

diethyl {2-[3-(hypoxanthin-9(6H)-yl)-2-(2-(diethoxyphosphoryl)-ethoxy)propoxy]ethyl}phosphonate (1427428-91-8) + (L)-phenylalanine ethyl ester hydrochloride (3182-93-2) → C56H72N8O13P2 (1427428-95-2)

Guidance literature:

diethyl {2-[3-(hypoxanthin-9(6H)-yl)-2-(2-(diethoxyphosphoryl)-ethoxy)propoxy]ethyl}phosphonate; With pyridine; trimethylsilyl bromide; In acetonitrile; at 20 ℃; Inert atmosphere;

(L)-phenylalanine ethyl ester hydrochloride; With pyridine; 2,2'-dipyridyldisulphide; triethylamine; triphenylphosphine; at 60 - 70 ℃; for 72h; Inert atmosphere;

DOI:10.1021/jm301893b

Reference yield:

tetraethyl {[(3-hydroxypropane-1,2-diyl)bis(oxy)]bis(ethylene)}bis(phosphonate) (1427428-88-3) → C56H72N8O13P2 (1427428-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; water

3.1: trimethylsilyl bromide; pyridine / acetonitrile / 20 °C / Inert atmosphere

3.2: 72 h / 60 - 70 °C / Inert atmosphere

With pyridine; trimethylsilyl bromide; di-isopropyl azodicarboxylate; water; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; acetonitrile; 1.1: |Mitsunobu Displacement;

DOI:10.1021/jm301893b

Reference yield:

C22H40O9P2 (1370018-78-2) → C56H72N8O13P2 (1427428-95-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; palladium dichloride; hydrogenchloride / methanol; water / 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / -30 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; water

4.1: trimethylsilyl bromide; pyridine / acetonitrile / 20 °C / Inert atmosphere

4.2: 72 h / 60 - 70 °C / Inert atmosphere

With pyridine; hydrogenchloride; trimethylsilyl bromide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; water; triphenylphosphine; trifluoroacetic acid; palladium dichloride; In tetrahydrofuran; methanol; water; acetonitrile; 2.1: |Mitsunobu Displacement;

DOI:10.1021/jm301893b

upstream raw materials:

tetraethyl {[(3-hydroxypropane-1,2-diyl)bis(oxy)]bis(ethylene)}bis(phosphonate)

diethyl {2-[3-(hypoxanthin-9(6H)-yl)-2-(2-(diethoxyphosphoryl)-ethoxy)propoxy]ethyl}phosphonate

(L)-phenylalanine ethyl ester hydrochloride

C₂₂H₄₀O₉P₂